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Clinical Trial Summary

This Phase 1b/2 study is designed to assess the safety and efficacy of ibrutinib in combination with lenalidomide and rituximab in subjects with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) not eligible for transplant.


Clinical Trial Description

Phase 1b: In the dose escalation portion of the study, various cohorts with escalating doses of lenalidomide may be explored, using the 3+3+3 principle for dose determination. Phase 2: This will be conducted as an international, multicenter, open-label study. Eligible subjects will receive ibrutinib, lenalidomide and rituximab. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02077166
Study type Interventional
Source Pharmacyclics LLC.
Contact
Status Completed
Phase Phase 1/Phase 2
Start date March 13, 2014
Completion date December 17, 2020

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