Postoperative Cognitive Dysfunction Clinical Trial
Official title:
Postoperative Cognitive Dysfunction in Elderly
Interventional Study of Early Postoperative Cognitive Dysfunction in Elderly Patients
Undergoing General Anesthesia
The main purpose of this study is to determine the incidence of early postoperative
cognitive dysfunction in elderly patients and its time course.
This study will first evaluate the preoperative cognitive function of elderly patients based
on several criteria including complete patient history, laboratory and instrumental exams,
and the following measures in order to identify conditions and pathologies that may
influence cognitive function.
- Mini Mental State Examination
- Geriatric Index of Comorbidity
- Geriatric Depression Scale
The following neuropsychological tests will be performed on the same day within 7 days of
surgery (baseline):
- Trail Making Test B-A
- Digit Span
- Digit Symbol Substitution Test
The three cognitive function assessments will be repeated at the following postoperative
time points and the change from the preoperative baseline to each time will be evaluated:
- Day 2 (time point 1)
- Day 4 (time point 2)
- Between days 85 and 90 (time point 3)
If the patient seems confused before the postoperative administration of these tests, the
Neecham Confusion Scale will be used to evaluate the patient for the presence of
postoperative delirium; if delirium is not detected, the cognitive function tests will be
administered.
This study has three specific aims:
1. To define the frequency of occurrence of early post-operative cognitive dysfunction and
its time course.
2. To assess risk factors for the onset of post-operative cognitive dysfunction and
possible causal factors.
3. to compare our results with those from the international literature.
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