Type 2 Diabetes or Obesity Without Diabetes Clinical Trial
Official title:
Search for Biological Markers of Orosensory Perception of Fatty Acids in Healthy Subjects and Possible Modifications in Patients With Type 2 Diabetes and in Obese Non-diabetic Patients.
Animal studies have shown that stimulation of the lingual lipid-receptor, CD 36, is
accompanied by the rapid secretion of hormones in the digestive tract (incretines). We aim
to determine in healthy humans whether the orosensory perception of fatty acids is followed
by a modification in plasma levels of digestive tract hormones (cholecystokinin, GIP, GLP-1,
secretin, pancreatic peptide, peptide YY, insulin) and metabolic markers from adipose tissue
(leptin, ghrelin, adiponectin).
We also aim to determine whether the hormonal response induced by orosensory stimulation by
lipids is modified:
- in patients with type 2 diabetes
- in obese non-diabetic patients We expect to show an increase in biological markers
biological, and more particularly in certain digestive hormones such as Pancreatic
polypeptide, GIP, GLP-1…after stimulation of the lingual lipid receptor, CD36. We will
also determine whether or not this response is modified in patients with type 2
diabetes and in obese non-diabetic patients.
We also wish to measure the subjects' gustatory detection threshold for a fatty acid
(linoleic acid), and to determine whether there is a relationship between the orosensory
perception threshold for linoleic acid and the physiological status of the subjects. In
order to achieve this, the thresholds for healthy subjects will be compared with thresholds
for obese and diabetic subjects. Expected results: the threshold of detection for linoleic
acid in healthy subjects will be lower than that in obese or diabetic patients.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label