Implantation Rate of Vitrified Blastocysts Clinical Trial
Official title:
Randomized Controlled Trial Comparing the Implantation Rate of Vitrified-warmed Blastocysts With and Without Artificial Shrinkage Before Vitrification
In our centre, the implantation rate of frozen blastocysts (cryopreserved using
vitrification)was 20,3% (Van Landuyt et al. 2011). This implantation rate is lower when
compared to data from other observational studies. Retrospective studies have shown that
artificial shrinkage of the blastocoelic cavity (also called collapse) and dehydration of
the blastocyst just before vitrification can have a positive effect on the survival after
warming. This collapse can be induced by using a laser. The study of Iwayama et al. 2010 has
shown a similar survival rate but an increase in the implantation rate of collapsed
blastocysts compared to non-collapsed blastocysts.
The aim of the study is to investigate the effect of artificial shrinkage by laser-induced
collapse on the implantation potential of vitrified-warmed day 5 or day 6 blastocyst stage
embryos in a prospective randomised controlled trial.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment