Invasive Group B Streptococcal Disease Clinical Trial
Official title:
Genetic Susceptibility to Invasive Streptococcal Disease
Invasive bacterial infection is a dangerous but relatively uncommon disease where bacteria
spread deep into the body causing diseases like blood poisoning ('bacteraemia'), pneumonia,
meningitis and others. The various bacteria of the streptococcus family are an important
cause, often leading patients to require intensive care despite which, for some strains, one
in five patients die. One notable form is called necrotising fasciitis, a condition where
bacteria rapidly spreads through and destroys the layers of tissue just under the skin.
As individuals vary greatly in their risk of developing such serious infections,
investigating how the genome, the inherited blueprint of our bodies, of these patients
differs from that of healthy volunteers can help to explain why the disease develops in some
and not others. For some streptococcal bacteria such as Streptococcus pneumoniae this
approach is already proving successful; for others such as the "Group A" strain
(Streptococcus pyogenes) it has yet to be explored but carries excellent potential.
The investigators have secured the support of the Lee Spark Necrotising Fasciitis Foundation
to recruit from their membership survivors of streptococcal infections and some of their
family members. The investigators will also ask infection specialists from NHS hospitals to
invite patients they have looked after. The investigators also have a small existing
collection. Taking part would involve registering information on a website, discussing the
study on the telephone and then providing us with a sample of saliva from which the
investigators can isolate DNA. The investigators would prepare the sample for analysis of the
genome and compare the patients with both their family and an existing reference collection
from healthy volunteers using technology that reads the DNA code.
Our study will be a first key step in renewing efforts to understand the determinants of
invasive streptococcal infection, which is important for developing better treatments and
vaccines.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01933646 -
Burden of Invasive Group B Streptococcal (GBS) Disease in Young Infants in China
|
N/A | |
| Recruiting |
NCT02812576 -
Burden of Invasive Group B Streptococcal Disease in Infants and Resistance Surveillance in China
|
N/A |