Dialysis Membranes and Hemodynamic Tolerance Clinical Trial
Official title:
Assessment of Subjective and Hemodynamic Tolerance of Different High- and Low-flux Dialysis Membranes in Patients Undergoing Chronic Intermittent Hemodialysis: a Randomized Controlled Trial
Background:
High- and low-flux dialysis membranes made of different materials may correlate with various
hemodynamic tolerance profiles. This study aims to investigate hemodynamic response and
incidence of hypotensive episodes by comparing some of the most commonly used high- and
low-flux dialyzers.
Methodology:
The study was designed as an open label, randomized, cross-over investigation, including 25
patients undergoing chronic hemodialysis. Four polysulfone dialyzers of 1.8 m2, A
(Revaclear, Gambro), B (Helixone high flux, Fresenius), C (Xevonta, BBraun) and D (Helixone
low flux, Fresenius), were compared with each other. The hemodynamic profile was assessed
with a non-invasive technique and patients were asked to provide tolerance feedback through
a questionnaire.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment