Glucose Metabolism After Transplantation Clinical Trial
Official title:
The Effect of Magnesium Supplements on Early Post-transplantation Glucose Metabolism: a Randomized Controlled Trial.
Hypomagnesemia is common early after transplantation, especially in association with
calcineurin inhibitors and predicts diabetes after transplantation. Magnesium improves
glycemic control and insulin sensitivity in diabetics and insulin resistant subjects without
diabetes but this was never evaluated in transplant recipients.
The aim of the study is to assess whether magnesium improves glycemic control and insulin
sensitivity early after transplantation.
The study is an open label study in which adult hypomagnesemic renal transplant recipients
are randomized the first 2 weeks after kidney transplantation to magnesium oxide or no
supplementation.
The hypothesis is that magnesium supplementation in renal transplant recipients exerts a
beneficial effect on glycemia and the development of diabetes after transplantation.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment