Eletrophysiology of iPS-derived Cardiomyocytes Clinical Trial
Official title:
Cellular Reprogramming as a Tool to Characterise the Cellular Electrophysiology of Familial Arrhythmia
Hereditary cardiac arrhythmias (genetically caused disturbances of heart rhythm) are life
threatening conditions affecting otherwise healthy young individuals. Due to the
inaccessibility of heart tissue, the abnormal electrical current(s) in the heart cells
causing the rhythm disturbance can be difficult to study in detail and therefore in many
cases remain untreatable. The investigators propose to study heart cell electrical function
from such patients by reprogramming skin cells to become stem cells and then differentiating
them to heart muscle cells.
The hypothesis of the study is that the differentiated cardiac cells will display electrical
abnormalities dependent on the mutation causing the disease. These abnormalities can
therefore provide a clue as to the nature of the mutation causing the disease or information
about its effective management
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