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Early Spontaneous Breathing in Acute Respiratory Distress Syndrome — BiRDS  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Early Spontaneous Breathing in Acute Respiratory Distress Syndrome

Clinical Trial Summary

The care of acute respiratory distress syndrome (ARDS) has been significantly improved by learning from experimental and physiological research works and by a series of randomized controlled trials. The mortality of this syndrome remains however high. Numerous experimental and clinical works demonstrated that a ventilatory mode authorizing the patient to make, from the acute phase, spontaneous breathing cycles superimposed on assistance delivered by the ventilator (BIPAP-APRV mode) allowed to improve gas exchanges and hemodynamic tolerance of the ventilation while reducing the need for sedative drugs. This ventilatory mode could also reduce the risk of diaphragmatic dysfunction induced by ventilation. Consequently, our hypothesis is that this ventilatory mode could allow a reduction of mortality in ARDS patients.

The aim of this multicenter, prospective, randomized, controlled, open study is to compare the effects of two ventilatory strategies on the mortality of ARDS patients and placed under mechanical ventilation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01862016
Study type Interventional
Source University Hospital, Angers
Contact
Status Active, not recruiting
Phase N/A
Start date February 28, 2013
Completion date May 2019
View Details
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