Whole Body Catabolisme Induced by Glucocorticoids Clinical Trial
Official title:
Glucocorticoid Induced Inhibition of IGF-I Activity: Exploring Underlying Mechanisms.
The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.
Long-term treatment with glucocorticoid induces a general state of catabolism and increases
insulin resistance. The underlying mechanisms are insufficiently characterized, however
glucocorticoid induced changes of Growth Hormone (GH) and the Insulin-like growth factor I
(IGF-I) appear to be of outmost importance.
We wish to investigate the mechanism behind glucocorticoid induced catabolism and insulin
resistance.
More specific we wish to investigate:
- Whether glucocorticoid induces IGF-I inhibiting substances in serum or interstitial
fluid that block the ability of IGF-I to phosphorylate its receptor in vitro
- Whether glucocorticoid inhibits intracellular IGF-I and insulin signaling in vitro and
in vivo
- The mechanisms by which growth hormone counteracts the CG-mediated inhibition of IGF-I
action
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science