Chronic Lymphocytic Leukemia (CLL) Clinical Trial
Official title:
HO11415: Phase II Study of Bendamustine and Rituximab Induction Chemoimmunotherapy Followed by Maintenance Rituximab (Rituxan®) and Lenalidomide (Revlimid®) in Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)
CLL/SLL is an incurable disease with conventional chemotherapy, and there are limited
treatment options available for patients who have become refractory to fludarabine- and
alkylating-agent based regimens. Bendamustine is a recently FDA-approved agent with
significant activity in CLL/SLL, including significant activity in the setting of
fludarabine-refractory disease. However, durations of remission following
bendamustine/rituximab combination therapy tend to be short in patients with heavily
pre-treated disease or who have already received rituximab.
The incorporation of a maintenance therapy to overcome the shorter remission durations in
this population is a reasonable and feasible option. In considering potential options for
treatment of CLL/SLL as a maintenance strategy following induction chemotherapy, lenalidomide
and rituximab are appealing options based on their convenient dosing schedules and recent
evidence of acceptable toxicity and promising efficacy in combination therapy.
n/a
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