Diabetes Mellitus Clinical Trial
Official title:
Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization
The aim of this prospective, randomized, controlled study is to investigate the effect of pretreatment with intravenous Alprostadil on the incidence of CIN in a high-risk population of patients with both type 2 diabetes mellitus (T2DM) and CKD undergoing coronary angiography, and evaluate the influence of such potential benefit on short-term outcome.
The number of cardiac angiography and percutaneous coronary interventions (PCI) has
increased steadily in recent years. This has resulted in the increasing incidence of
contrast-induced nephropathy (CIN). Major risk factors for CIN include older age, diabetes
mellitus (DM), chronic kidney disease (CKD).
The aim of this prospective, randomized, controlled study is to investigate the effect of
pretreatment with intravenous Alprostadil on the incidence of CIN in a high-risk population
of patients with both type 2 diabetes mellitus (T2DM) and CKD undergoing coronary
angiography, and evaluate the influence of such potential benefit on short-term outcome.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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