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Metformin for the Treatment of Endometrial Hyperplasia

Endometrial Hyperplasia Clinical Trial

Official title:
Metformin for the Treatment of Endometrial Hyperplasia

Clinical Trial Summary

The purpose of this study is to see if metformin will be effective in making endometrial hyperplasia without atypia better by returning the tissue to a normal state.

Clinical Trial Description

This is a multi-institutional pilot clinical trial designed to estimate the response rate and safety of metformin for the treatment of simple and complex endometrial hyperplasia (EH) without atypia. Enrollment of patients will occur at UNC-Chapel Hill and Southern Pines Women's Health Center. Fifteen patients will be enrolled over the course of 1 year. Metformin will be initiated at 850 mg orally once daily, and titrated up to twice daily over a minimum of 1 months time. Treatment will last 12 weeks and then patients will undergo repeat endometrial biopsy to assess for regression or persistence of EH. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01685762
Study type Interventional
Source UNC Lineberger Comprehensive Cancer Center
Contact
Status Completed
Phase Early Phase 1
Start date January 10, 2013
Completion date December 1, 2015
View Details
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