Non Small Cell Lung Cancer (NSCLC) Clinical Trial
Official title:
Randomized Phase II Study of Gefitinib Plus Nimotuzumab Versus Gefitinib in Patients With Advanced Non-small Cell Lung Cancer: Dual-agent Molecular Targeting of EGFR (DATE)
Combining nimotuzumab to gefitinib may not only potentiate cellular cytotoxicity, but may also assist in overcoming inherent or acquired resistance to gefitinib alone.
Reversible EGFR tyrosine kinase inhibitors (TKI), such as gefitinib, were shown to be
effective in patients with non-small cell lung cancer (NSCLC). However, patients almost
invariably develop resistance to TKIs and have disease progression. Nimotuzumab is a
humanized monoclonal antibody targeting the EGFR.
Combining nimotuzumab to gefitinib may not only potentiate cellular cytotoxicity, but may
also assist in overcoming inherent or acquired resistance to gefitinib alone.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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