Clinical Trials Logo

Clinical Trial Summary

Compassionate use of orphan drug 3,4-Diaminopyridine(DAP) in Treatment of Lambert Eaton Myasthenic Syndrome (LEMS). 3,4-DAP is used to decrease the muscle weakness associated with LEMS and hopefully will decrease the need for prednisone and all other therapies that were previously required to control symptoms. How long a patient will take 3,4 DAP depends upon if he/she is seeing benefits from the medication or experiencing side effects that will prevent them from continuation in the study.


Clinical Trial Description

3,4-diaminopyridine (3,4-DAP) decreases symptoms of weakness in patients with LEMS, and therefore can be used to decrease the amount of immune modulation therapy needed to provide an equivalent degree of disease control. ;


Study Design

N/A


Related Conditions & MeSH terms

  • Lambert-Eaton Myasthenic Syndrome
  • Syndrome

NCT number NCT01373333
Study type Expanded Access
Source The Cleveland Clinic
Contact
Status No longer available
Phase N/A
Start date September 1997

See also
  Status Clinical Trial Phase
Completed NCT02970162 - Phase 3 Study to Evaluate Efficacy of Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS) Phase 3
Completed NCT05408702 - Exercise in Autoimmune Myasthenia Gravis and Myasthenic Syndromes
Recruiting NCT06441825 - Patient Observation With Environmental and Wearable Sensors in Myasthenia Gravis
Completed NCT01511978 - Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome Phase 2
Completed NCT00004832 - Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome N/A
No longer available NCT02189720 - Expanded Access Study Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS),Congenital Myasthenic Syndrome
No longer available NCT00994916 - Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine
Approved for marketing NCT00872950 - 3,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS)