Compression Fracture of Thoracic Vertebral Body Clinical Trial
Official title:
Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
The purpose of this study is to
1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image
compared with MR imaging as standard reference.
2. Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual
noncalcium images, such as the morphologic signs, visual qualitative detection, and
quantitative values.
Patients with multiple compression fractures and in those with chronic fracture, determining
which vertebra to treat is frequently difficult. In such patients, the treatment location is
commonly determined from findings at imaging, which includes magnetic resonance (MR)
imaging, bone scintigraphy, and computed tomography (CT).
The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra
that is to be treated.
MR imaging provides information on anatomic vertebral collapse and the loss of normal T1
high signal intensity from the marrow space of vertebrae with acute fractures. Loss of
normal T1 high signal intensity indicates the presence of BME, which is the important sign
for the PVP treatment of VCFs.
Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine
from contrast agent-enhanced CT examinations.We expect that the same technique can be used
to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow
accessible for CT diagnosis.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01913587 -
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|
N/A |