A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas

Newly Diagnosed Pediatric High Grade Glioma Clinical Trial

Official title: A Pilot Study to Evaluate the Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides With Poly-ICLC for Children With Newly Diagnosed Malignant Brain Stem Gliomas, Non-Brainstem High-Grade Gliomas, Recurrent Low-Grade Gliomas or Recurrent High Grade Gliomas

Status Active, not recruiting

Clinical Trial Summary

The overall objective of this pilot study is to collect immunological and safety data following administration of vaccinations with HLA-A2. This data will be used to decide whether a larger study of clinical efficacy is warranted.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Glioma
• Newly Diagnosed Pediatric High Grade Glioma
• Newly Diagnosed Pediatric Pontine Glioma
• Recurrence
• Recurrent Pediatric High Grade Glioma
• Recurrent Pediatric Low Grade Glioma

• NCT number: NCT01130077
• Study type: Interventional
• Source: University of Pittsburgh
• Status: Active, not recruiting
• Phase: Phase 1
• Start date: February 2009
• Completion date: December 31, 2025