The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium

Post-tetanic Count on One Arm, the Other Arm is the Control Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01086176
• Other study ID #: MaisonneuveRH-09092
• Status: Completed
• Phase: N/A
• First received: March 10, 2010
• Last updated: April 26, 2010
• Start date: March 2010
• Est. completion date: April 2010

Study information

• Verified date: March 2010
• Source: Maisonneuve-Rosemont Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Health Canada
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to see how long does the effect of a post-tetanic facilitation last on subsequent train-of-four. The investigators hypothesis is that the effect last at least 30 minutes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: April 2010
• Est. primary completion date: April 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Patient having general anesthesia in dorsal decubitus with both arm available for at least an hour and a half

Exclusion Criteria:

• Age >75 or <18

• Neuromuscular disease

• difficult laryngoscopy predicted

• Allergy to rocuronium

• Malignant hyperthermia

• Full stomach

• Drugs the influence neuromuscular blockers

• Decision of the clinician to exclude his patient

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Post-tetanic Count on One Arm, the Other Arm is the Control

Intervention

Device:
• NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)
on one side, we do a post-tetanic count, on the other side we don't, after, we do train-of-four on both sides and check the difference

Locations

Country	Name	City	State
Canada	Hopital Maisonneuve-Rosemont	Montréal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Maisonneuve-Rosemont Hospital

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The difference at 30 minutes after the post-tetanic count between the TOF% in both arms, we expect a difference of more than 10%
Secondary	The difference at 30 minutes after the post-tetanic count on the T1% (of the calibrated T1) in both arms, we expect a difference of more than 10%
Secondary	The difference of the slope of recuperation on TOF and T1% after a post-tetanic count vs the control arm that had no tetanic stimulation