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Treatment of Advanced Head and Neck Cancer

Carcinoma, Squamous Cell of Head and Neck Clinical Trial

Official title:
Treatment of Advanced Head and Neck Cancer With Opioid Growth Factors: Phase II

Clinical Trial Summary

This study will investigate the efficacy of opioid growth factor (OGF) on tumor size and survival in patients with head and neck cancer who have failed standard therapy.

Clinical Trial Description

The major focus of the study will involve assessment of tumor response, patient survival, tolerance to drug, quality of life, depression, pain management and nutrition. During the study we will begin to study the kinetics of opioid growth factor (OGF) exogenous administration and the relationship between plasma OGF levels, stage of disease and length of treatment. Apart from potentially having growth inhibitory action on cancer, OGF may have some psychological and other biological effects which may prove to be beneficial in the patient's treatment. Presently there is no effective therapy or quality of life adjuvants for the 30,000 Americans who develop head and neck cancer yearly. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00982696
Study type Interventional
Source Milton S. Hershey Medical Center
Contact
Status Terminated
Phase Phase 2
Start date February 2008
Completion date November 2011
View Details
See also
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