Human Papilloma Virus-Related Carcinoma Clinical Trial
Official title:
Human Papillomavirus Screening and Vaccine Readiness Program
Public Health Research Institute (PHRI) is carrying out a 15 month research and advocacy project with the goals of generating critical data on acceptability, identifying determinants and facilitators of HPV vaccine uptake in adolescent girls; and investigating physicians' attitudes to identify predictors of intention to recommend immunization in Mysore, India.
Discovery of the viral etiology of cervical cancer has opened up the possibility of primary
prevention through vaccination. High-risk sexually transmitted types of human papillomavirus
(HPV) have been identified as a necessary agent in cervical carcinogenesis, and work on
vaccine development has progressed rapidly. Vaccines for HPV types 16 and 18, which are
implicated in ~70% of cervical cancers, as well as types 6 and 11, which cause genital
warts, have been shown to be effective and have been licensed in the last year. Modeling
studies have indicated that an HPV vaccine could be cost-effective even alongside existing
screening programs. Ideally, girls should be vaccinated before the onset of sexual activity,
and estimates suggest that introduction of an HPV vaccination at age 12 could reduce
lifetime cervical cancer incidence by up to 94%. As with any new technology, the success of
HPV vaccination will be dependent on levels of acceptability and uptake. Given the need for
parental consent in India, research into parental acceptance is of vital importance.
Although parental acceptance of vaccination against sexually transmitted infections (STI)
including HPV, appears high in other parts of the world, there is little data in India. In
previous research from other parts of the world, the biggest concern identified was that
vaccinations may disinhibit risky sexual activity among adolescents. Other attitudes and
beliefs that may influence parental uptake of an HPV vaccine include fear of potential side
effects, concern about giving children too many vaccinations, the belief that vaccinations
may cause disease, and religious and cultural taboos against vaccination. There is a
critical need to develop data and experience that will provide the information needed by
policymakers prior to the introduction of a cervical cancer vaccine in India.
The present research will be guided by the ecological framework and identify where the locus
of HPV vaccine decision-making lies in an Indian setting. This project will explore
household, peer and authority figure influencers in vaccine uptake. This process will
include qualitative research methods such as focus group discussions and one-on-one
interviews..
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Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01539668 -
Hybrid Capture Test on Mobile Unit Program to Improve Cervical Cancer Screening in Brazilian Rural and Remote Areas
|
Phase 0 |