End Stage Renal Disease Clinical Trial
Official title:
A Randomized Clinical Trial for Estimating the Effects of Pomegranate Juice Consumption by Hemodialysis Patients on Oxidative Stress, Infections, Cardiovascular Events and Mortality
Pomegranate juice (PJ) consumption by hemodialysis patients will reduce the oxidative stress and the incidence of infections, cardiovascular events and mortality.
The mortality rate in patients with end stage renal failure is substantially higher than in
the general population, and deaths are mainly attributable to cardiovascular diseases and
infections. There is accumulating evidence that supports the role for oxidative stress in
damaging the immune system and in the pathogenesis of cardiovascular diseases in
hemodialysis patients, therefore antioxidative treatment, which will reduce oxidative
stress, may be beneficial.
Pomegranate juice contains antioxidants such as soluble polyphenols, tannins and
anthocyanins and was shown to have anti-inflammatory, anti- bacterial and
anti-atherosclerotic properties in mice and humans. However,the effects of pomegranate juice
on oxidative stress, infections and cardiovascular events in hemodialysis patients are still
not documented.
This is a randomized preventive intervention trial on hemodialysis patients from one
dialysis centre in Israel. The patients will be enrolled and randomized to receive
pomegranate juice or placebo. Patients will be followed for one year. The objective of this
study is to investigate the effects of pomegranate juice (PJ) consumption by hemodialysis
patients on the changes in oxidative stress and the incidence of infections, cardiovascular
events and mortality.
;
Primary Purpose: Prevention
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