Lymphoma Clinical Trial
Official title:
Follow-up Observational Study of the Randomised Intergroup Trial of First Line Treatment for Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphoma With CHOP-Like Chemotherapy Regimen With or Without the Anti-CD20 Antibody Rituximab (IDEC-C2B8) [MINT]
RATIONALE: Treatment for diffuse large B-cell non-Hodgkin's lymphoma may cause side effects
and secondary cancers later in life. An observational study that evaluates patients after
undergoing six courses of combination chemotherapy with or without rituximab and radiation
therapy may help doctors predict a patient's response to this treatment and help plan the
best treatment.
PURPOSE: This observational study is evaluating patients with diffuse large B-cell
non-Hodgkin's lymphoma to see how well treatment on clinical trial CAN-NCIC-LY9 works.
OBJECTIVES:
- Gain information on the long-term efficacy of 6 courses of CHOP (cyclophosphamide,
doxorubicin hydrochloride, prednisone, and vincristine)-like chemotherapy with vs
without rituximab (plus involved-field radiotherapy to primary bulky disease) in young
patients with good-prognosis diffuse large B-cell non-Hodgkin's lymphoma treated on
protocol CAN-NCIC-LY9.
- Gain information on late toxicities, including secondary neoplasm occurring in young
good-prognosis patients treated on protocol CAN-NCIC-LY9.
OUTLINE: This is a multicenter study.
Patients successfully completing treatment on protocol CAN-NCIC-LY9 are followed every 3
months for 2 years, every 6 months for 3 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 667 patients will be accrued for this study.
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N/A
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