A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis

Secondary Progressive Multiple Sclerosis Clinical Trial

Official title:

A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis: Single Centre, Phase 2 Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00257855
• Other study ID #: 2005-001949-42
• Status: Completed
• Phase: Phase 2
• First received: November 22, 2005
• Last updated: February 5, 2010
• Start date: November 2005
• Est. completion date: February 2009

Study information

• Verified date: February 2009
• Source: University College London Hospitals
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency
• Study type: Interventional

Clinical Trial Summary

A present there is no safe treatment for reducing rate at which disability worsens in people with secondary progressive multiple sclerosis. Recent research has suggested the possibility that drugs that act by blocking the entry of sodium into nerve cells can protect nerve fibres in the brain and spinal cord. In this trial, the investigators will test whether one such drug, called lamotrigine, can prevent damage to nerve fibres and reduce the rate at which MS worsens. The period of treatment in the trial will run for 2 years.

Description:

At present, there is no safe, widely applicable treatment that is capable of reducing the rate at which disability advances in secondary progressive multiple sclerosis (SPMS). There is good evidence that the primary cause of disability is axonal degeneration within the CNS, so there is considerable interest in developing treatments which can protect axons from degeneration. Experimental work by members of our group has established that axons may degenerate upon exposure to the inflammatory mediator nitric oxide. The mechanism of the damage implies that protection might be afforded by the novel approach of partially blocking sodium channels, and our group and others have recently demonstrated that drugs including flecainide, phenytoin and lamotrigine can reduce axonal degeneration when optic nerves or spinal roots are exposed to nitric oxide, and in experimental autoimmune encephalomyelitis.

Aims: To assess whether the sodium channel blocker lamotrigine has a neuroprotective, disease modifying effect on a) the rate of axonal degeneration and b) the accumulation of disability in patients with SPMS.

Methodology: We propose to recruit 120 people with SPMS in whom progression rather than relapse is the major cause of increasing disability into a double blind parallel group controlled trial lasting two years in which random allocation would be made to receive treatment with either lamotrigine or placebo. We anticipate that patient recruitment, follow-up and trial management could be achieved readily across four proposed sites in London. The primary endpoint would be an effect of treatment on cerebral atrophy, which correlates with other MR markers of axonal loss, and which can be measured reliably and sensitively using recently developed MR techniques. The trial is powered to detect a 60% beneficial effect on the rate of development of cerebral atrophy. Secondary endpoints would include effects of treatment on spinal cord atrophy and on clinical measurements of impairment/disability. MR measures of brain volume and cervical spinal cord cross-sectional area and scores of clinical impairment/disability would be determined at entry, and then after 12 and 24 months. Brain volume would be measured additionally at 6 and 18 months. Clinical follow-up would occur every 3 months, and interim analysis is planned at 12 months.

Utilization of results: A phase 2 trial of sodium channel blockade in SPMS is timely, given recent advances arising from experimental and imaging work. A successful outcome would enable sufficiently powered phase 3 trials to be implemented, but perhaps more significantly would demonstrate a novel, safe neuroprotective strategy to reduce long-term disability in this disorder.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: February 2009
• Est. primary completion date: January 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Age 18 to 60

• Progression rather than clinical relapse is the major cause for increased disability over the preceding 2 years

• EDSS 4.0-6.5

Exclusion Criteria:

• Very rapid deterioration in EDSS, >2 points over 6 months

• Use of Mitoxantrone in the preceding year

• Use of sodium channel blockers or calcium channel blockers in the preceding 2 weeks

• Use of corticosteroids in preceding 2 months

• Use of neuroprotective agents or immunosuppressants in the preceding 6 months

• Evidence of significant hepatic or renal impairment either in clinical history or blood results.

• Prior untoward reactions to lamotrigine, or severe temperature dependent symptoms

• Contraindications to MRI

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Multiple Sclerosis
• Multiple Sclerosis, Chronic Progressive
• Neoplasm Metastasis
• Sclerosis
• Secondary Progressive Multiple Sclerosis

Intervention

Drug:
• Lamotrigine

Locations

Country	Name	City	State
United Kingdom	National Hospital for Neurology and Neurosurgery	London

Sponsors (1)

Lead Sponsor	Collaborator
University College London Hospitals

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in central brain volume on MRI using the 'Loseff method'
Secondary	Change in whole brain volume on MRI using Brain Boundary Shift Integral
Secondary	Number and volume of new T2 high intensity lesion volume on T2 weighted MRI
Secondary	Number and volume of new T1 low signal lesion volume on T1 weighted MRI
Secondary	Ratio of new T1 to new T2 lesions on MRI
Secondary	Change in magnetisation transfer ratio in normal MRI normal appearing white matter and normal appearing grey matter.
Secondary	Change in upper cervical cord cross sectional area using the 'Loseff method' on MRI
Secondary	Change in Kurtzke's Extended Disability Scaling Score.
Secondary	Change in Multiple Sclerosis Functional Composite.
Secondary	Change in Multiple Sclerosis Impact Scale.