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Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Assessment of Ventilation-perfusion Abnormalities in Patients With Smoking-related Airways Disease in Stable Condition and the Effect of Bronchodilator Therapy

Clinical Trial Summary

Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.

Clinical Trial Description

As in Brief description ;

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00180843
Study type Interventional
Source Imperial College London
Contact
Status Terminated
Phase N/A
Start date September 2005
Completion date February 2008
View Details
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