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NCT ID: NCT04729699 Completed - Migraine Clinical Trials

Changes and Associations Between Cervical Range of Motion, Pain, TMJ Range of Motion and Quality of Life in Migraineurs Applying Physical Therapy

Start date: July 13, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effects of physiotherapy program and review the associations between neck movements, pain, temporomandibular joint (TMJ) movements and quality of life in individuals with migraine.

NCT ID: NCT04729517 Completed - Clinical trials for Allergic Rhinitis Due to Allergens

Efficacy and Safety Study of AI201901 in Allergic Rhinitis Patients

HILARIA
Start date: April 20, 2021
Phase: Phase 3
Study type: Interventional

This is a prospective, national, randomized, multicenter, parallel group, Phase III study that evaluates the effects of AI201901 in Allergic Rhinitis patients, where they will spray twice a day against azelastine into both nostrils during a 28-day follow-up period.

NCT ID: NCT04729257 Completed - Clinical trials for Cognitive Functioning of Healthy Individuals

Norms Expansion and Validation for IntelliSpace Cognition

Start date: March 8, 2021
Phase: N/A
Study type: Interventional

This study aims to expand the normative dataset for Philips IntelliSpace Cognition to include ages 18-49 and 80+ and aims to validate two new digital tests.

NCT ID: NCT04728802 Completed - Covid19 Clinical Trials

Proxalutamide Treatment for Hospitalized COVID-19 Patients

Start date: February 1, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of Proxalutamide as a treatment for hospitalized COVID-19 male and female patients.

NCT ID: NCT04728750 Completed - Clinical trials for Solid Pseudopapillary Neoplasm of the Pancreas

Laparoscopic Enucleation of Frantz's Tumor of the Pancreas

Start date: December 1, 2020
Phase:
Study type: Observational

The present study describes a 32-year-old female patient, in whom a preoperative imaging diagnosis confirmed a mass in the junction of the body and tail of the pancreas. Based on the anamnesis, on the preoperative diagnosis, and on the general status of the patient, the decision was made to performed laparoscopic enucleation of the pancreatic tumor. The operation and postoperative recovery passed without complications. A minimally invasive surgical approach should be applied whenever the dimensions and the localization of the tumor permits it, bearing in mind all the benefits and advantages that this surgical technique has to offer.

NCT ID: NCT04728464 Completed - Clinical trials for Crowding of Anterior Mandibular Teeth

Pain, Acceptance, and Discomfort With Periodontally Accelerated Osteogenic Orthodontics (PAOO)

Start date: August 29, 2018
Phase:
Study type: Observational

Patients will be examined in the Orthodontic Department of the University of Damascus Dental School. Patients who will be treated in conjunction with the PAOO procedure and subjects who will meet the inclusion criteria will be included then the initial diagnostic records (diagnostic gypsum models, internal and external oral photographs, as well as radiographic images) will be studied to ensure that the selection criteria will be accurately matched. This study aims to assess patients' acceptance of the PAOO procedure as well as the levels of pain and discomfort associated with this treatment.

NCT ID: NCT04727905 Completed - Clinical trials for Injury of Multiple Muscles and Tendons at Lower Leg Level

The Effect of Supplementing Different Solutions on Firefighters' Simulated Fire Rescue Training

Start date: December 30, 2020
Phase: N/A
Study type: Interventional

One of the three major tasks of firefighters is disaster rescue, and fire rescue accounts for the majority. They must wear personal protective equipment (PPE) at the fire site during execution. This set of equipment plus other equipment required for rescue will always It weighs up to 40 kg, and the rescue environment is extremely hot and the rescue mission must be carried out in a short time. Under this extremely high pressure, firefighters must have speed, agility, strength and endurance that are different from ordinary people. However, after performing the above fire rescue tasks, firefighters often lose a lot of water; therefore, the purpose of this study is to explore the impact of water and electrolyte supplementation on physical recovery after firefighters perform fire rescue tasks. A total of 24 field firefighters from the Fire Department were research subjects. In the past research on firefighters, there was no research on the effect of water and electrolyte supplementation on physical recovery after dehydration after performing fire rescue tasks. Therefore, in this study, the body composition was measured before and after the special training of firefighters simulated fire rescue. , Collect venous blood; Replenish electrolytes in sections after training, and take venous blood, urine and saliva for tests at 15, 30 and 60 minutes to analyze relevant values and perform strength tests to observe firefighters The state of physical recovery. The experiment was divided into three groups. The control group only drank 1 liter of pure water, the sports drink group was supplemented with commercially available sports drinks, and the mint flavored sports drink group was supplemented with mint flavored commercially available sports drinks. Drink 1 liter of liquid within 60 minutes after training; 8 people in each of the 3 groups are randomly assigned. The results of the experiment were analyzed by analysis of variance (ANOVA), and Tukey-Kramer test was used to detect whether there are differences between different treatments, and P<0.05 represents statistical significance.

NCT ID: NCT04727866 Completed - Clinical trials for Spinal Cord Injuries

Brain Plus Spinal Stimulation for Cervical SCI

Start date: January 4, 2021
Phase: N/A
Study type: Interventional

The goal of this project is to strengthen residual corticospinal tract (CST) connections after partial injury using combined motor cortex and spinal cord stimulation to improve arm and hand function after spinal cord injury (SCI). To do this, the investigators will test the combination of transcranial magnetic stimulation (TMS) with transcutaneous spinal direct current stimulation (tsDCS) in individuals with chronic cervical SCI.

NCT ID: NCT04727827 Completed - Oncology Clinical Trials

Pharmacogenomic-Guided Supportive Care in Hematopoietic Cell Transplantation

IMPPACT
Start date: February 1, 2021
Phase: N/A
Study type: Interventional

Hematopoietic cell transplantation (HCT) is the only curative treatment modality for many hematologic malignancies. Morbidity and mortality rates have declined drastically over the years, secondary to improvements in both transplant techniques and pharmacotherapies, including immunosuppressants, anti-infectives, analgesics and other supportive care medications. Despite advances in patient care, toxicities associated with HCT (e.g., graft-versus-host disease (GVHD), infection, pain, anxiety, depression, mucositis, nausea/vomiting) continue to pose challenges in patient care and have a significant impact on quality of life. (QOL). A recent study demonstrated subjects randomized to intensive supportive care had a clinically significant improvement in their QOL during hospitalization and up to 3 months post-transplant compared to those receiving standard care. Further follow up evaluations have evaluated the impact of focused palliative care/symptom management on QOL metrics - inclusive of Edmonton Symptom Assessment surveys (ESAS). In other malignant settings, i.e. solid tumor, ESAS has been noted as an effective measure of symptoms control and the utilization of this assessment is linked to positive outcomes. The American Society of Clinical Oncology (ASCO) has designated QOL as the second most relevant metric for post-transplant patient care behind survival, making the optimization of supportive care pharmacotherapy a clinically relevant subject to investigate. Pharmacogenetics (PGx) uses an individual's genetic factors, such as single nucleotide polymorphisms (SNPs), to personalize therapy or dose selection. SNPs encode drug-metabolizing enzymes, transporters, and targets that can significantly impact drug efficacy and toxicity. With the growing complexity of both antineoplastics and supportive care, oncologists have less time to manage each subject's myriad of supportive care concerns by trial and error. Suboptimal management of symptoms compromises potential benefits from cancer therapy, disrupts clinic workflow, increases emergency room visits, and affects both patient satisfaction and reimbursement. Genetic variation is well documented across the human genome and affects a subject's response to medications regarding efficacy and toxicity. The genome is quickly becoming a pragmatic tool that can assist oncologists and other providers in optimizing supportive care for subjects with cancer.

NCT ID: NCT04727567 Completed - Clinical trials for Comorbidities and Coexisting Conditions

Evaluation of a Personalized Care Management Program for High Hospital Utilizers

Start date: April 23, 2020
Phase:
Study type: Observational

This randomized clinical trial intends to evaluate the effectiveness of enrollment in Atrium Health's Multiple Visit Patient (MVP) care management program compared to usual care on reducing 12-month total inpatient hospital utilization among patients with high past volume of hospital inpatient stays.