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NCT ID: NCT04965207 Not yet recruiting - Clinical trials for Chronic Total Occlusion of Coronary Artery

EvaLuAtion On the cHaracteristics of the True/False lUmen and Its Prognostic Value for cOronary CTO Patients Just Before Stent Implantation

Start date: October 1, 2021
Phase:
Study type: Observational

IVUS will be used to evaluate the ratio of false lumen to occluded segment, the ratio of false lumen to stent length, the location characteristics of false lumen and its prognostic value for perioperative complications, 1-year late lumen loss and MACCE events in patients with coronary CTO.

NCT ID: NCT04963608 Not yet recruiting - Clinical trials for HER2-positive Advanced Breast Cancer

RWS of Inetetamab HER2 Positive Advanced Breast Cancer

Start date: July 2021
Phase:
Study type: Observational

This non-Interventional study will describe and analyze the clinical use of Inetetamab in clinical practice in the treatment of HER2 positive advanced breast cancer in the real world.

NCT ID: NCT04960306 Not yet recruiting - Clinical trials for Clostridium Difficile Infection

Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infection

FILTRATE
Start date: November 1, 2023
Phase: Phase 3
Study type: Interventional

Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infectious diseases with a high mortality rate (6-30%). The treatment of CDI, especially the recurrent form of the disease is still considered a challenge. The FILTRATE randomized controlled trial aims to investigate the safety and efficacy of fecal filtrate transplantation in the treatment of recurrent CDI and compare it with conventional fecal microbiota transplantation (FMT).

NCT ID: NCT04957862 Not yet recruiting - Clinical trials for Hypertensive Intracerebral Hemorrhage

Robotic Assisted Evacuation of Subacute and Chronic Supratentorial Deep Hypertensive Intracerebral Hemorrhage

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Robotic Assisted Evacuation of Subacute and Chronic Supratentorial Deep Hypertensive Intracerebral Hemorrhage for Accelerating Functional Rehabilitation (RESCUE-CHAIN): a Multi-center Randomized Controlled Trial

NCT ID: NCT04957849 Not yet recruiting - Clinical trials for Hypertensive Intracerebral Hemorrhage

Acute Hypertensive Cerebral Hemmorrhage Surgery

NET-OCEAN
Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The Neuroendoscopic, Trans-occipital Approach Evacuation of Acute Hypertensive Cerebral Hemmorrhage Combined Low-drainage Surgery: a Multi-center Clinical Trial

NCT ID: NCT04957706 Not yet recruiting - Clinical trials for Anterior Cruciate Ligament Rupture

Diagnostic Study of ACL Rupture With Anterior Drawer Test at 90° of Hip Flexion

Start date: September 1, 2021
Phase:
Study type: Observational

For patients with anterior cruciate ligament rupture, the existing physical examinations have certain limitations. The researchers improved the traditional anterior drawer test in clinical work, maintained the flexion of the knee and flexion of the hip, and observed the displacement of the tibia. Good diagnostic effect, but no research statistics. The purpose of this study is to explore the effectiveness of the 90° of hip flextion anterior drawer test in the diagnosis of anterior cruciate ligament rupture.

NCT ID: NCT04956497 Not yet recruiting - Clinical trials for Extracorporeal Membrane Oxygenation Complication

Registry Study of Extracorporeal Cardiopulmonary Resuscitation (eCPR) in China

ECPR-China
Start date: September 1, 2021
Phase:
Study type: Observational [Patient Registry]

The data of patients undergo extracorporeal cardiopulmonary resuscitation (eCPR) will be collected and analyzed. This study will provide useful information about the indication, the start time and others to improve the outcome of ECPR.

NCT ID: NCT04955821 Not yet recruiting - Clinical trials for VAP - Ventilator Associated Pneumonia

Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS

Start date: May 1, 2024
Phase:
Study type: Observational

VAP(Ventilator-associated pneumonia)is the most common complication of mechanical ventilation in severely ill patients. VAP is defined as pneumonia occurring 48 hours after patients receive mechanical ventilation, including pneumonia occurring within 48 hours after extubation. It is one of the important causes of hospital-acquired infection, and the incidence of VAP in children on mechanical ventilation is about 10%, or 7/1000 days of mechanical ventilation, and the overall mortality is 10-24%.Research has so far explained the relationship between bacteria isolated from human biological samples and VAP pathogens. Most studies are limited to the level of bacterial species, and there are few reports on bacterial genotyping, and there is a lack of scientific basis for the pathogenesis of VAP caused by bacteria in ventilator pipeline. The aim of the study is to investigate pathogen of the sputum in deep respiratory tract of patients with mechanical ventilation in PICU by the means of second generation sequencing (NGS).

NCT ID: NCT04953676 Not yet recruiting - Clinical trials for Anterior Cruciate Ligament Rupture

A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

This study intends to perform round-tunnel and flat-tunnel ACL reconstruction technique in 144 patients, and compare the clinical outcomes of the two surgical procedures through follow-up.

NCT ID: NCT04953364 Not yet recruiting - Amputation Clinical Trials

Self-Management for Amputee Rehabilitation Using Technology.

SMART
Start date: August 15, 2022
Phase: N/A
Study type: Interventional

Lower Limb Amputations (LLAs) are a substantial burden on the Canadian health services with nearly 50,000 cases reported between 2006 and 2011. To address the challenging nature of a LLA (e.g., decreased mobility, pain, depression), patients need to go through extensive rehabilitation programs. Effective self-management programs can help those with LLA to monitor their own condition and improve their quality of life. However, a lack of self-management programs, a limited healthcare budget, and a decrease in quality of services (e.g. shorter lengths of stay for inpatients and rapid movement to outpatient services) pose further challenges for patients with LLA. Self-management programs can be provided to clients through online mobile technologies (e.g., tablet) and offer accessible, low-cost, and potentially augmentative rehabilitation after discharge, in both urban and rural areas. To address these needs, an online educational and training platform for individuals with LLA called, Self-Management for Amputee Rehabilitation using Technology (SMART) was designed and developed. SMART focuses on LLA education, prosthetic limb management, and weekly support of peers. It is monitored by a trainer through a website. SMART will be evaluated in men and women with LLA aged 50 years and over, admitted to prosthetic rehabilitation throughout BC and ON. SMART has the potential to influence a client's post-LLA needs with direct (e.g., individual's health) and indirect (e.g., healthcare utilization) benefits. The purpose of this randomized controlled trial is to evaluate the effect of SMART in community dwelling older adults with unilateral, above or below, knee amputation.