A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Osteoporosis Clinical Trial

— CTROP  

Official title:

Calcitonin Receptor Gene Polymorphisms in Patients With Osteoporosis and Chronic Periodontitis-An Observational Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02273128
• Other study ID #: D129206005
• Status: Completed
• Phase: N/A
• First received: October 21, 2014
• Last updated: April 18, 2015
• Start date: June 2014
• Est. completion date: November 2014

Study information

• Verified date: April 2015
• Source: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
• Contact: n/a
• Is FDA regulated: No
• Health authority: India: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Description:

Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).

Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.

Bone loss is a common feature shared between periodontal disease and osteoporosis.

Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: November 2014
• Est. primary completion date: October 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 35 Years to 60 Years

Eligibility

Inclusion Criteria:

• Male and Female

• Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study

Exclusion Criteria:

• Patients who are Systemically compromised and under medications such as steroids.

• Patients who smoke.Pregnant and lactating mothers are excluded from the study

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Chronic Periodontitis
• Generalized Chronic Periodontitis
• Osteoporosis
• Periodontitis

Intervention

Genetic:
• CTR Gene
2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Locations

Country	Name	City	State
India	Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre	Hyderabad	Andhra Pradesh

Sponsors (1)

Lead Sponsor	Collaborator
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Country where clinical trial is conducted

India, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Calcitonin gene polymorphism	Collection of blood samples and running the samples by PCR	5 Months	No