Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

Status Not yet recruiting

Clinical Trial Summary

People with Alzheimer's disease are at an increased risk of bone fracture. Some studies have shown that those taking donepezil have a lower rate of bone fractures, but the reasons for this are unknown. The purpose of this study is to measure the effect of donepezil treatment on bone metabolism factors including bone mineral density, bone turnover markers, and bone quality. Participants in this study will have a bone density test and have blood samples collected at the baseline study visit. Participants will then be randomly assigned to donepezil or matching placebo to be taken daily by mouth for 12 months. Blood samples will be collected at 6 and 12 months. A repeat bone density test will be performed at 12 months. Participants will also complete questionnaires at each study visit.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Osteoporosis

Clinical Trial Details

NCT number	NCT06041789
Study type	Interventional
Source	Duke University
Contact	Connie Thacker
Phone	(919) 681-9807
Email	connie.thacker@duke.edu
Status	Not yet recruiting
Phase	Phase 2
Start date	March 31, 2024
Completion date	March 2025

View Details

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