Clinical Trials Logo
NCT number NCT03280693
Study type Observational
Source Cairo University
Contact
Status Completed
Phase N/A
Start date May 2015
Completion date November 2015

Clinical Trial Summary

Body composition, bone mineral density (BMD), and body balance are important factors that threaten postural control. They act as vital elements in the vicious circle that leads to fracture occurrence in elderly population, particularly postmenopausal women.


Clinical Trial Description

- The purpose of the current study was to evaluate the relationships among body mass index (BMI), body balance, and BMD (g/cm²) in postmenopausal women to be able to identify risk factors for fractures.

- Forty-eight postmenopausal women participated in this study. Body balance was assessed using Berg Balance Scale (BBS), while BMD of the lumbar spine was measured by dual energy X-ray absorptiometry (DEXA) scan.

The positive correlation between body balance and BMD in the current study can be explained that balance is controlled by sensory input, central processing, and neuromuscular responses. The sensory components consist of the vestibular, visual, and proprioceptive systems. An effective motor response requires an intact neuromuscular system and sufficient muscle strength to return the COG within the BOS when balance is disturbed. Postural balance in individuals with osteoporosis is significantly worse than in healthy individuals. Moreover, it was determined that balance scores in individuals with osteoporosis were 11% worse than scores of healthy individuals. Furthermore, exaggerated thoracic kyphotic curve is not only a disfiguring effect of osteoporosis but may also play a significant role in gait disorder, instability, and risk of falls.

In addition, back pain has a harmful impact on both balance and functional mobility in women with osteoporosis. Individuals with back pain may reduce their level of physical activity and, as a result, become weak in muscles required for balance and functional mobility. Impairment of the musculoskeletal and/or the neuromuscular system may negatively affect both balance and functional mobility.

In the same context, it was proved that women with decreased BMD and increased thoracic kyphosis presented greater body sway in the anterior/posterior direction on the force platform indicating more displacement of foot center of pressure (COP). They also confirmed that postmenopausal women with low BMD and increased thoracic kyphosis depend more on the hip strategy to maintain their postural control. This in turn probably causes more displacement of foot COP, thus causing greater body sway in all directions in comparison with the ankle strategy. it was also showed that women with loss of bone mass and increased thoracic kyphosis presented less foot COP displacement in the AP direction compared with the control group (with normal bone mass and normal thoracic curve.

The current study results also revealed that BMI was negatively correlated with both BMD and body balance in postmenopausal women. This can be illustrated that obese elderly women are often afraid of falls and sustaining fractures, so they prefer immobility and minimize their physical activity as much as possible. Because bone is formed when needed and resorbed when not needed as known as Wolff's law, BMD decreases and osteopenia/osteoporosis develops. Low BMD affect bone health as it leads to fragile weak bone and this in turn disturbs postural control and body balance. Additionally, obese women fail to control their center of gravity (COG) within base of support (BOS) disturbing their postural control and body balance, increasing risk of falls and making them more liable to fractures.


Study Design


Related Conditions & MeSH terms


See also
  Status Clinical Trial Phase
Completed NCT00092066 - A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227) Phase 3
Not yet recruiting NCT03040765 - Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis Phase 3
Active, not recruiting NCT02922478 - Role of Comorbidities in Chronic Heart Failure Study N/A
Recruiting NCT02566655 - Clinical Trial of Intravenous Infusion of Fucosylated Bone Marrow Mesenchyme Cells in Patients With Osteoporosis Phase 1
Recruiting NCT02635022 - Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study N/A
Recruiting NCT02617303 - Prevention of Falls and Its Consequences in Elderly People N/A
Recruiting NCT02616627 - Association Between DXA Results and the Complications, Clinical Courses and Outcomes in Chronic Dialysis Patients N/A
Active, not recruiting NCT02559648 - Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis Phase 2
Not yet recruiting NCT02223572 - Secondary Fracture Prevention in Patients Who Suffered From Osteoporotic Fracture N/A
Completed NCT02003716 - DeFRA Questionnaire as an Anamnestic Form N/A
Not yet recruiting NCT01854086 - Compliance and Persistence With Osteoporosis Treatment and Attitude Towards Future Therapy Among Post-menopausal Israeli Women During Drug Treatment or Drug Holiday N/A
Unknown status NCT01913834 - Nasally and sc Administered Teriparatide in Healthy Volunteers Phase 1
Active, not recruiting NCT01401556 - C-STOP Fracture Trial Phase 3
Completed NCT01757340 - Calorie Restriction With Leucine Supplementation N/A
Completed NCT02143674 - Muscle Strengthening Exercises and Global Stretching in Elderly N/A
Completed NCT01694784 - Understanding and Discouraging Overuse of Potentially Harmful Screening Tests N/A
Recruiting NCT01549028 - Osteoporosis in Chronic Obstructive Pulmonary Disease (COPD) N/A
Completed NCT01504230 - Multi-joint Coordination Underlies Upright Balance Control in Elderly With Osteoporosis N/A
Completed NCT01387672 - Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study Phase 3
Completed NCT01439139 - Bone UltraSonic Scanner (BUSS): Validation Study N/A