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Clinical Trial Summary

The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.


Clinical Trial Description

The investigators will perform paired iliac crest bone biopsies in postmenopausal women who meet standard romosozumab treatment indications and are being prescribed romosozumab by their treating physician. All study volunteers will have a bone biopsy procedure prior to starting therapy, and then an identical procedure at the contralateral side either 3-6 weeks ("early") or 6-8 months ("late") after starting therapy. This is not a randomized clinical trial testing the efficacy of a drug - the investigators will not be assigning volunteers to a specific osteoporosis therapy, though the investigators will randomize volunteers to either the early or late second biopsy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05688969
Study type Interventional
Source Massachusetts General Hospital
Contact Mackenzie Jordan
Phone 617-726-6129
Email MRJORDAN@mgh.harvard.edu
Status Recruiting
Phase N/A
Start date June 14, 2023
Completion date December 2028

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