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DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

Osteoporosis, Postmenopausal Clinical Trial

Official title:
DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

Clinical Trial Summary

To determine whether the musculoskeletal adaptations to bone-loading exercise can be significantly augmented in older women (aged 60-85) with low bone mass (osteopenia; T-scores <-1.0 and >-2.5) or moderate osteoporosis (T-scores < -2.5 and >= -3.0) and by restoring serum DHEAS to young adult levels by oral DHEA replacement.

Clinical Trial Description

This will be the first study to measure changes in areal bone mineral density (aBMD) and fat-free mass (FFM) in response to dehydroepiandrosterone (DHEA) alone and combined with exercise in postmenopausal women. The body of evidence from carefully executed Randomized Controlled Studies (RCTs) provides support for DHEA therapy to increase aBMD and FFM in older women. Less is known about whether DHEA therapy enhances the effects of exercise on the aging musculoskeletal system when an appropriate mechanical stimulus is applied. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03227458
Study type Interventional
Source University of Colorado, Denver
Contact
Status Active, not recruiting
Phase N/A
Start date February 12, 2018
Completion date June 2024
View Details
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