Osteogenesis Imperfecta and Balance

Osteogenesis Imperfecta Clinical Trial

Official title:

Efficacy of Whole Body Vibration on Balance and Motor Control in Children With Osteogenesis Imperfecta

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06010134
• Other study ID #: P.T.REC/012/002577
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2023
• Est. completion date: September 30, 2023

Study information

• Verified date: May 2023
• Source: South Valley University
• Contact: Nehad Abo-zaid, Assistant Professor
• Phone: +201008980727
• Email: dr.nehadahmed[@]svu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. Its severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems and problems with the teeth. Physiotherapy is aimed to strengthen muscles and improve motility in a gentle manner, while minimizing the risk of fracture, and the use of support cushions to improve posture.

Description:

This study aimed to assess the efficacy of Whole Body Vibration on balance and motor function in children with Osteogenesis Imperfecta. Whole body vibration (WBV) therapy is targeted at musculoskeletal strengthening and has been trialed in a variety of conditions. WBV has been shown to have therapeutic advantage in various osteopenic preclinical models and populations such as postmenopausal women (improved mobility, muscle strength, postural strength, and bone density) and children with osteogenesis imperfecta (improved mobility)

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: September 30, 2023
• Est. primary completion date: August 30, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Their age was ranging from six to twelve years

2. Children participated in this study were from both sexes

3. All children with stable medical and psychological status.

4. They were able to follow the verbal commands or instructions during testing.

Exclusion Criteria:

1. Children with visual or auditory problems.

2. Children with any cognitive problems.

3. Children without deformity

Related Conditions & MeSH terms

• Osteogenesis Imperfecta

Intervention

Other:
• Physical Therapy Program
Physical Therapy Program plus Whole Body Vibration

Locations

Country	Name	City	State
Egypt	South Valley University, Faculty of Physical Therapy	Qina

Sponsors (1)

Lead Sponsor	Collaborator
South Valley University

Country where clinical trial is conducted

Egypt, 

References & Publications (4)

Andersen PE Jr, Hauge M. Osteogenesis imperfecta: a genetic, radiological, and epidemiological study. Clin Genet. 1989 Oct;36(4):250-5. doi: 10.1111/j.1399-0004.1989.tb03198.x. — View Citation

Bishop N. Bone Material Properties in Osteogenesis Imperfecta. J Bone Miner Res. 2016 Apr;31(4):699-708. doi: 10.1002/jbmr.2835. Epub 2016 Mar 26. — View Citation

Folkestad L, Hald JD, Ersboll AK, Gram J, Hermann AP, Langdahl B, Abrahamsen B, Brixen K. Fracture Rates and Fracture Sites in Patients With Osteogenesis Imperfecta: A Nationwide Register-Based Cohort Study. J Bone Miner Res. 2017 Jan;32(1):125-134. doi: — View Citation

Rauch F, Travers R, Parfitt AM, Glorieux FH. Static and dynamic bone histomorphometry in children with osteogenesis imperfecta. Bone. 2000 Jun;26(6):581-9. doi: 10.1016/s8756-3282(00)00269-6. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Over All Stabiity Index	Stability Index	at day 0
Primary	Over All Stabiity Index	Stability Index	at day 90
Primary	Medio lateral Stabiity Index	Stability Index	at day 0
Primary	Medio lateral Stabiity Index	Stability Index	at day 90
Primary	Antro posterior Stabiity Index	Stabiity Index	at day 0
Primary	Antro posterior Stabiity Index	Stabiity Index	at day 90