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Efficacy of Exercise on Quality of Life and Physical Function in Patients With Knee Osteoarthritis

Pain Clinical Trial

Official title:
Efficacy of Strength and Aerobic Exercise on Patient-reported Outcomes in Patients With Knee Osteoarthritis - A Randomised Controlled Trial.

Clinical Trial Summary

The overall contribution of this study is to increase the knowledge of the efficacy of strength and aerobic exercise on knee related quality of life, knee pain, and physical function in patients with knee osteoarthritis (OA). Knee OA is one of the most important diseases within musculoskeletal conditions affecting a considerable number of people worldwide. This randomized controlled trial will involve one intervention group delivered strength exercises and one group delivered aerobic exercise (ergometer cycling). The two intervention groups will be compared to a control group undergoing usual care. Cost-effectiveness analysis will be performed comparing the three groups. The study is funded from The Research Council of Norway.

Clinical Trial Description

The trial aimed to recruit 207 study participants randomly allocated to three arms. The participants had to have symptomatic knee osteoarthritis verified by grade 2-3 using the Kellgren and Lawrence radiographic classification system, and they had to have knee pain most of the days the last month and fulfil 2/3 of the ACR clinical criteria. Participants with other serious comorbidities or self-reported BMI >35 were included. The interventions consisted of structured strength training program over 12-14 weeks, and a structured stationary cycling program for 12-14 weeks. Primary outcome was the KOOS knee-related quality of life subscale at the 1 year follow-up. Secondary outcomes were other patient reported outcomes, muscle strength, and peak oxygen consumption at the 4-month and 1 year follow-up, and over time (1-year). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01682980
Study type Interventional
Source Oslo University Hospital
Contact
Status Active, not recruiting
Phase N/A
Start date March 2013
Completion date December 2025
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