Osteoarthritis Of Knee Clinical Trial
By taking certain antidepressant in early postoperative period,which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.
In this study, the investigators are going to investigate the efficacy of Duloxetine on
pain, physical function, mental health and quality of life in patients underwent TKAs.
The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the
basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to
8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used
to evaluate the two groups before and after operation for 4 and 8 weeks.
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