Increased Blood Glucose Levels After Steroid Injection

Osteoarthritis, Knee Clinical Trial

Official title:

Increased Blood Glucose Levels After Steroid Injection Into Osteoarthritic Knee in Diabetic Patients' Type 2

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06228911
• Other study ID #: GH; 5615
• Status: Completed
• Phase: N/A
• Start date: January 15, 2020
• Est. completion date: September 15, 2023

Study information

• Verified date: January 2024
• Source: Syrian Private University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

a sample of 600 patients diagnosed as Knee osteoarthritis injected with 40 mg triamcinolone, recorded their morning fasting blood glucose levels for 7 days before injection used as the baseline blood glucose level, which was compared with FBS levels for 14 days after steroid injection. Our study compared the differences in blood glucose changes between HbA1c >7% and HbA1c ≤7% groups and those between insulin and non-insulin treated groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 600
• Est. completion date: September 15, 2023
• Est. primary completion date: September 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Age > 18 years, patients with knee osteoarthritis diagnosed according to American College of Rheumatology (ACR) Criteria (17), and grade1-3 in Kallgren-Laurence radiographic scale (18), whom failed to response to medical treatment including paracetamol and nonsteroidal anti-inflammatory medication, and to physical therapy, checking their blood glucose values daily.

Exclusion Criteria:

Patients who were unable to provide consent, patients had any contraindications to corticosteroids, patients who had received oral corticosteroid in the past 6 months or corticosteroid injection in the previous 3 months, patients who had no monitoring HbA1c level before injection or also whom had not monitor blood glucose levels before or after injection.

Related Conditions & MeSH terms

• Diabete Type 2
• Diabetes Mellitus, Type 2
• Osteoarthritis, Knee

Intervention

Drug:
• steroid (triamcinolone)
triamcinolone is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions

Locations

Country	Name	City	State
Syrian Arab Republic	Faculty of Medicine, Damascus University, Syria	Damascus

Sponsors (1)

Lead Sponsor	Collaborator
Syrian Private University

Country where clinical trial is conducted

Syrian Arab Republic, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	high blood glucose	glucose increases after steroid dose	3 years
Primary	low blood glucose	glucose decreases after steroid dose	3 years