Osteoarthritis, Knee Clinical Trial
Official title:
Physical Exercise Guided by Active Video Games for Optimizing Clinical and Psychosocial Outcomes in Older Adults With Knee and/or Hip Osteoarthritis Under a Community-based Rehabilitation Model.
Population aging is currently an issue of primary relevance, constituting an enormous challenge for institutions and society. On the other hand, osteoarthritis (OA) is the most prevalent arthropathy in the elderly, strongly related to loss of functional capacity, limitation of daily activities, increased musculoskeletal pain, and deterioration of quality of life. More specifically, knee and hip OA represent a significant burden for health systems, and in Chile, they are among the ten most frequent diseases in the elderly. The technological development of the last decades has allowed the incorporation of several therapeutic alternatives for the intervention of the elderly, such as virtual reality, which allows interaction with multiple digital environments. Active video games (AVG) or exergames, carried out through commercial non-immersive virtual reality systems, have been proposed as a feasible, innovative, and entertaining alternative to optimize conventional physical rehabilitation (CPR). AVG in healthy older people and those with neurocognitive conditions effectively improves clinical and psychosocial outcomes. However, it has been recommended to advance the study of the effects of AVGs in people with musculoskeletal pathologies, such as knee and hip OA. Accordingly, the purpose is to analyze the effects of an AVG-guided physical exercise protocol adjunct to CPR on functional mobility in older adults with knee and/or hip OA.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | November 28, 2024 |
Est. primary completion date | November 28, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years to 84 Years |
Eligibility | Inclusion Criteria: - Age =60 and =84 years. - Diagnosis of mild or moderate OA of the knee and/or hip. - Independent walking capacity of at least 15 meters. Exclusion Criteria: - Inability to interact with active video games. - Undergoing treatment with opioids or other medications with a potential influence on the outcomes of interest. - <13 points in the abbreviated version of the Mini-Mental State Examination (MMSE-EFAM). - OA associated with infectious, autoimmune, fractures or surgery. - Participate or have participated in another physical-cognitive rehabilitation program during the last 3 months. |
Country | Name | City | State |
---|---|---|---|
Chile | Centro de Salud Familiar (CESFAM) Lorenzo Arenas | Concepción |
Lead Sponsor | Collaborator |
---|---|
Cristian Alvarez | National Fund for Research and Development in Health, Chile |
Chile,
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* Note: There are 35 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Functional mobility. | Timed Up and Go (TUG). Number of seconds required to get up from seated position, walk 3 m, turn, and return to seated position on chair. | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Lower body strength. | 30-s chair stand. Number of full stands in 30 s with arms folded across chest | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Upper body strength. | 30-s arm curl. Number of bicep curls in 30 s holding hand weight (women 5 lb; men 8 lb) | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Aerobic endurance. | 2-min step test. Number of full steps completed in 2 min,raising each knee to point midway between patella and iliac crest (score is number of times right knee reaches target) | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Lower body flexibility | Chair sit-and-reach. From sitting position at front of chair, with leg extended and hands reaching toward toes, number of inches (+or - ) from extended fingers to tip of toe | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Upper body flexibility. | Back scratch. With one hand reaching over shoulder and one up middle of back, number of inches between extended middle fingers (+ or - ) | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Hand grip strength | Number of kg measured with a Jamar dynamometer. | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Functional disability. | Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire. Score obtained on the scale of items grouped into 3 dimensions: pain, stiffness and difficulty in performing tasks. Scores range from 0 to 96, where 0 represents the best health status and 96 the worst possible status. | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Cognitive performance. | Montreal Cognitive Assessment (MoCA) test. Score obtained in the development of the tests. It considers executive functions, attention, abstraction, memory, language, viso-constructive abilities, calculation and orientation. MoCA scores range from 0 to 30; higher scores indicate a better cognitive performance. | Three-time points. Baseline (pre-intervention); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Pain intensity. | Visual Analog Scale (VAS). 100 mm straight line with two labels ("no pain" and "worst possible pain") at each end. | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Pressure pain threshold | Wagner® FPX-25 algometer. It is expressed in kilogram/cm2. | Five-time points. Baseline (pre-intervention); at week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Change in Health-related quality of life | SF-12v2 Chile-Spanish Questionnaire. Score from 0-100 points. Assessment of 8 dimensions (physical functioning [PF], role-physical [RP], bodily pain [BP], general health [GH], vitality [VT], social functioning [SF], role-emotional [RE], and mental health [MH]), and two summary scores (physical component summary [PCS] and mental component summary [MCS]). | Three-time points. Baseline (pre-intervention); and week 10 (after 30 sessions from baseline). In addition, four weeks after the completion of the intervention. | |
Secondary | Adherence to treatment | Number of effective assistances at the end of treatment. A participant with an attendance =2/3 of the total (30 sessions) is considered "adherent" (=20 sessions). | One-time point. At week 10 (after 30 sessions from baseline). | |
Secondary | Change in User satisfaction | The average score of 3 questions (overall level of satisfaction, expectation fulfillment, and recommendations to others) using a scale of 1 to 7 points, where 1 is the worst evaluation, and 7 is the best evaluation. | Three-time points. At week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). | |
Secondary | Change in Therapeutic alliance | Subscale of the Pain Rehabilitation Expectations Scale (PRES). The score ranges from 1 to 44; a higher score is a higher therapeutic alliance. | Three-time points. At week 4 (after ten sessions from baseline); at week 7 (after 20 sessions from baseline); and week 10 (after 30 sessions from baseline). |
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