Optic Neuritis Clinical Trial
Official title:
Linking Optic Nerve Lesion Length at MRI and the Retinal Axonal Loss at 12 Months From a Clinical Episode of Optic Neuritis
This study evaluates the length of optic nerve lesion on 3D-DIR sequence as an imaging biomarker predictive of retinal axonal loss and visual disability, 12 months after the occurence of a first clinical episode of optic neuritis.
Neurologists and Neuro-Ophthalmologists are in need for reliable and robust imaging
biomarkers enabling to predict retinal axonal loss and visual disability after clinical
episode of optic neuritis (ON). Length of optic nerve lesion measured on MRI may be one of
them.
The aim of our study is to measure the association between the extent of inflammatory
demyelinating process on optic nerve at the acute of ON and the retinal degenerative process
following optic nerve injury.
The investigators planned to include 50 patients suffering from a recent clinical episode of
ON.
Extent of demyelinating inflammatory process will be assessed by the length of optic nerve
double inversion recovery (DIR) hypersignal at the acute phase of ON.
The axonal degenerative process following optic nerve demyelinating injury will be assessed
by retinal atrophy measured on optical coherence tomography at 12 months after ON, by visual
disability measured on low vision contrast acuity scale and by microstructural quality
analysis of optic nerve measured on diffusion tensor imaging sequence of the optic nerve.
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