Use of Long-acting Bupivacaine In Lower Extremity Amputation

Status Terminated

Clinical Trial Summary

The purpose of this investigator-initiated study is to assess the use of liposomal bupivacaine in major extremity amputation and its effects on post-operative opioid narcotic use, length of stay, and in-hospital costs. Liposomal bupivacaine is an encapsulated, injectable amide anesthetic intended for use in long-acting local anesthesia. It has been shown in randomized trials to be effective in reducing post-operative pain while reducing opioid narcotic use and length of hospital stay following several surgical procedures, particularly after total knee arthroplasty. Extremity amputation is a painful operation often performed in seriously ill or debilitated patients, often related to infection, trauma or malignancy. Application of liposomal bupivacaine in extremity amputation is not well described. The investigators intend to enroll adults greater than age 18 years of age who are to undergo major extremity amputation. Patients will receive targeted injections of liposomal bupivacaine during their procedure. Patient pain scores, total opioid use, and length of hospital stay will be tracked. Patients receiving liposomal bupivicaine will be compared to similarly matched subjects who received standard anesthesia regimens without liposomal bupivicaine. The investigators hypothesize that liposomal bupivicaine used during major amputation decreases opioid use, hospital stay, and in-hospital costs.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04360421
Study type	Interventional
Source	Loma Linda University
Contact
Status	Terminated
Phase	Phase 4
Start date	April 21, 2020
Completion date	August 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04095624` - Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion	N/A
Completed	`NCT04484610` - Appropriate Opioid Quantities for Acute Pain - Pharmacist Study	Phase 4
Recruiting	`NCT04598074` - Opioid Package Prototype (OPP)	N/A
Recruiting	`NCT06033599` - Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement	Phase 3
Recruiting	`NCT06032559` - Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment	Phase 3
Completed	`NCT05845177` - Persistent Pain After Hip Replacement
Completed	`NCT03268551` - MEMO-Medical Marijuana and Opioids Study
Completed	`NCT03570320` - Does Altering Narcotic Prescription Methods Affect Opioid Distribution Following Select Upper Extremity Surgeries?	N/A
Completed	`NCT04526236` - Influence of Aging on Perioperative Methadone Dosing	Phase 4
Completed	`NCT05593341` - Opioid Education in Total Knee Arthroplasty	N/A
Recruiting	`NCT05877157` - Pain AND Opioids After Surgery
Recruiting	`NCT06055205` - A Pain and Coordination Plan for Reduced Opioid Use After Accidental Injuries	N/A
Recruiting	`NCT03675386` - Reducing Opioid Use for Chronic Pain Patients Following Surgery	N/A
Suspended	`NCT05001789` - Cognitive Functioning in Opioid Use Disorder	N/A
Completed	`NCT04296396` - Opioid Prescription After Cesarean Trial	Phase 3
Not yet recruiting	`NCT04868552` - Naloxone Education in Total Joint Patients	N/A
Completed	`NCT03540030` - Opioid-Free Shoulder Arthroplasty	Phase 4
Terminated	`NCT06217380` - Feasibility and Acceptability of Oxygen Saturation Monitoring Using Masimo SafetyNet Alert (MSNA) in a Supportive Housing Program	N/A
Recruiting	`NCT05976646` - Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion	Phase 1/Phase 2
Terminated	`NCT03426137` - Relieving Acute Pain (RAP) Study: A Pilot Study	Phase 2