Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

Opioid-use Disorder Clinical Trial

— STAR-OM  

Official title:

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04706624
• Other study ID #: HanoiMU
• Status: Active, not recruiting
• Phase: N/A
• Start date: November 2, 2020
• Est. completion date: March 31, 2025

Study information

• Verified date: February 2024
• Source: Hanoi Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use (hereafter: meth use) among people with opioid use disorder who are in methadone maintenance therapy (MMT) in Vietnam. Over the past decade, the expansion of MMT has contributed to stemming both HIV and opioid epidemics. However, rising meth use threatens these achievements.

Evidence-based interventions such as Motivational Enhancement Therapy, Contingency Management, Matrix Model, and SMS reminders are effective in reducing meth use. The study will be conducted in the two largest cities in Vietnam, Hanoi and Ho Chi Minh City (HCMC), where there are the highest number of MMT patients and the highest burden of HIV cases. Building on the pilot work of the research team in Hanoi, through collaborative work with local MMT providers and patients, the investigators will first further refine adapted EBIs to develop adaptive strategies. The adaptive design includes: (1) Two frontline interventions: 6 weeks of contingency management then 6 weeks of weekly group educational sessions and 12 weeks of contingency management; (2) One (short-term) tailoring outcome: urine tests negative with meth metabolites in both week 11 and 12 are considered responsive to frontline interventions; (3) Three alternative interventions: those with positive outcomes will move to 12-week maintenance stage and receive two daily SMS reminders plus one weekly self-monitoring assessment messages. Non-responders will move to 12-week enhanced treatment stage and are randomly assigned to either Matrix group counseling only or Matrix group counseling plus contingency management.

The full randomization trial will be conducted with 200 HIV-positive and 400 HIV-negative MMT patients who report moderate- and high-risk meth use on self-screening with ASSIST or have urine positive with meth metabolites. In each location, the study will stratify participants by HIV status before randomizing them to one of two frontline interventions. Primary outcomes

• including HIV viral suppression, HIV risk behaviors, and meth use (reported and urine tests) - will be assessed at 12, 24 and 48 weeks. The study team also conducts ethnographic observations and in-depth interviews with MMT clinic managers, clinical staff and MMT patients to explore implementation barriers and facilitators.

Description:

1) To develop adaptive interventions, including two frontline interventions and four adaptive strategies, through collaborative processes (Aim 1): During Month 3 - 9, the investigators refine the EBIs to develop adaptive interventions.

1a) Assessment: The team conducts 4 Focus Group Discussions (FGDs) with MMT patients on local taxonomy and patterns of meth use, trigger situations, motivations for seeking treatment, motivations and barriers for participating in different EBIs, inputs/advice on proposed adaptive design, and barriers and facilitators for retention of participants in each of the adaptive steps.

1b) Decision: The team organizes a workgroup that involves MMT clinical staff, representatives of CBOs working with people who use drugs, social workers working with MMT patients, and MMT patients themselves to review the contents of FGDs in the Assessment step, experiences of pilot intervention in Hanoi, the conceptual and empirical evidence of EBIs to make recommendations on core contents of each EBI.

Contingency management is a 12-week or 6-week low-value escalating schedule. Participants give urine twice a week. Matrix group counseling involves twice weekly group sessions that last for about 60 to 90 minutes each. Group counseling focuses on relapse prevention. SMS-text: Participants receive automated, unidirectional, scripted, theory-based and culturally responsive text reminders twice daily plus a weekly self-monitoring assessment messages. The text messages are scripted across: 1) drug use, sexual risk reduction, physical health and HIV care (for HIV+ participants); and, 2) the theoretical construct of cognitive-behavioral therapy including understanding external and internal triggers; relapse prevention and relapse analysis and goal setting.

1c) Administration: At the end of the Decision step, the workgroup put together a framework for the adaptive design that include different interventions, sequence, decision rule and contents of interventions. This framework is presented and discussed in a second round of FGDs with target populations in each city.

2) Pilot implementation of adaptive interventions (Aim 1): During Month 3 - 9, the study team chooses one MMT clinic in each city for piloting the adaptive design. The pilot implementation, which lasts 12 weeks, aims to identify issues that need to be addressed before the full implementation. The pilot recruits 40 meth-using MMT patients (20 from each city, at least 10 HIV positive) and over-recruits women. Inclusion criteria for the pilot sample include: 1) 16 years old or older; 2) score of 4-26 (moderate risk) or 27+ (high risk) on ASSIST regarding meth use OR urine screen positive for metabolite of meth; 4) having a cell phone able to receive texts; (5) and willing to participate in treatment. These participants are excluded from the full implementation.

2a) Pilot Monitoring and Evaluation: The study team in each city monitors the overall operation of the pilot to ensure that interventions are carried out as planned. For each intervention session, a Master Behavioral Counselor and an ethnographer observe the implementation regarding content integrity, flow, location, message clarity, interventionist-participant interaction, participant attendance, engagement, and responsiveness. Second, after each phase of intervention implementation (self-screening, frontline interventions, decision stage, maintenance, enhanced treatment), a FGD is organized for all intervention facilitators and another with patients to understand their experiences and to gather feedback regarding potential modifications.

2b) Intervention modification and assessment finalization: The evaluation data helps to identify factors that may affect implementation and outcomes. Modifications to intervention characteristics to ensure the relevance of the intervention for target settings and populations are completed at this stage. This phase gives an opportunity to finalize the recruitment and retention strategies as well as assessment tools.

3) Full implementation of SMART design to compare effectiveness of two frontline interventions and four adaptive strategies (Aim 1) 3a) Selection of clinical settings to become intervention sites: Criteria for selecting clinics are established. Existing statistics are viewed and clinics that meet criteria are shortlisted. 20 MMT clinics are selected randomly from the shortlisted candidates (10 from Hanoi, 10 from HCMC).

3b) Intervention facilitator recruitment and training: The intervention team in each city includes one Master Behavioral Counselor with Master-level training in clinical psychology and two intervention coaches with bachelor degrees in social work, psychology or public health to support and ensure quality of implementation of the EBIs by MMT clinical staff. Both Master Counselor and intervention coaches are also facilitators for Matrix group counseling where MMT clinical staff will not be able to carry out themselves.

Once MMT clinics are selected, managers of these clinics nominate a physician, two counselors and one nurse to participate in the study as intervention facilitators. Before the start of intervention, all intervention staff at MMT clinics (1) receive didactic training on the theory behind the approach; (2) pass a knowledge test to evaluate their grasp of the concepts within and behind the approach; (3) watch a video of a Master Behavioral Counselor conducting intervention sessions and discuss the details of the session, and (4) conduct at least two pilot EBIs, which are recorded and observed by the HMU/UMP intervention team and the PIs. All subsequent interventions are audio recorded and coded to ensure the presence of essential elements of the intervention. Intervention staffs who have lower levels of intervention integrity or who have significant drift are provided detailed feedback and supervision.

3c) Participant recruitment and randomization: The 20 selected clinics are randomly assigned into 5 clusters (4 clusters of 4 clinics from the same city and 1 cluster of 4 clinics from two cities). In each cluster, CBO members and health care staff distribute flyers and CBO members working in each MMT clinic approach patients when patients come daily for their MMT dosages to invite them to participate in self-screening with tablet-based ASSIST as well as urine drug test and Quick HIV tests. Once agreed, CBO assist with self-screening processes. Individuals who participate in self-screening give verbal agreement to participate and receive compensation for their time. Those with low-risk scores and urine negative with meth metabolites are offered a Brief Intervention by trained CBO members. Those with reactive Quick HIV tests are referred to HIV care facilities if these participants have not done so.

Recruiting participants for adaptive interventions:

CBO members invite those who are at moderate-risk and high-risk scores for meth or have urine positive with meth metabolites to participate in the study. Those who express interest and provide contact information are referred to research assistants (RA) who then makes appointment to screen for eligibility. At each clinic, RA conduct a brief survey and collect urine sample to confirm recent meth use. The study over-recruits women as the majority of MMT patients in Vietnam are men. The study aims to recruit 200 HIV+ and 400 HIV-. Those who sign informed consent are enrolled in baseline assessment and electronically fingerprinted to create unique ID. Participants receive compensation for their participation in baseline assessment. Eligible participants at each clinic are first stratified by HIV status, and then randomized to low vs. high intensity frontline interventions.

4) Cost-effectiveness analysis of interventions (Aim 2) 4a) The cost-effectiveness analysis has two goals: 1) to determine whether any additional improvement in outcomes associated with interventions of different intensity and expense is worth the additional cost; and 2) to provide guidance to the Vietnam Ministry of Health on the cost of scaling-up and implementing the interventions. This analysis measures the increment in cost between contrasted interventions divided by the increment in outcomes. Effectiveness of each intervention for HIV+ and HIV- groups is measured by the estimated outcome probabilities for each outcome of interest, as in Aim 1.

4b) Costs are assessed from the point of view of the public health agency. The second analysis will include social costs. Implementation costs are calculated based on costs for each arm incurred by health care providers, including costs of implementing the intervention, mental health and drug treatment services used. An activity-based costing approach is used to estimate the cost of fielding the interventions in 20 MMT clinics. A template is used to collect data on salaries for personnel and consultants, physical resources, clinical supplies and miscellaneous charges that are required to deliver each intervention type. Data is collected from participants on medical visits and involvement with the criminal justice system. These differences are costed out using local pricing data. Per capita costs for each intervention are calculated by dividing the total cost for each site/arm by the number of participants in each arm at that site.

5) Ethnographic evaluation to identify the structural, provider, and patient-level factors that influence adoption and scale-up of interventions in MMT clinics. (Aim 3).

5a) Ethnographic interviews: Two ethnographic researchers conduct pre-post intervention in-depth interviews with 12 individuals in each cluster of clinics. Participants include MMT manager, MMT clinical staff, CBO members and patients who participate in interventions. In each cluster, at least 6 patients are selected. In-depth ethnographic interviews with these individuals take place immediately before enrollment and immediately after maintenance or enhanced treatments end.

With CBO and MMT staff, pre-intervention interviews explore experiences with current work; experiences with meth users, expectations of whether and how the interventions would work. Post-intervention interviews explore actual experiences with delivering interventions as well as perceived barriers and facilitators for adoption and scale-up.

With participants: first interviews explore family of origin, childhood and coming of age; histories of sexual and affective relations; histories of drug use and patterns of meth use; current social support; broader life goals; motivations to participate in the study, and expectations of how the interventions would work. Second interviews explore actual experiences and outcomes as well as motivations to stay in the interventions.

The Consolidated Framework for Implementation Research is used in all interviews to probe participant perceptions of the characteristics of the STAR-OM interventions, of outer settings, inner settings, provider characteristics and the implementation process.

5b) Ethnographic Observation: Two kinds of observations take place. The first, carried out with in-depth interviews of participants who consent to participate in this additional form of data collection, involves having two ethnographers spend time with them to observe activities such as individual meetings, group activities and other daily activities in the clinical and/or community settings. The second element of observation involve Master Counselors to observe randomly selected sessions of interventions in CM and CBT period and keep a logbook of SMS messages that are sent out to each participant in the study. A checklist is used to assess the fidelity of interventions contents and delivery. Master Counselors also assess other contextual information that is useful to determine whether interventions are effectively delivered. All observation periods are recorded with detailed field notes.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 667
• Est. completion date: March 31, 2025
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years and older

Eligibility

Inclusion Criteria:

• ASSIST scores from 10+ for methamphetamine use OR Confirmed methamphetamine use with urine analysis;

• Willing to provide at least three pieces of contact information;

• Having a cell phone to receive texts.

Exclusion Criteria:

• Psychosis or other interfering problems;

• Cannot understand study procedures as judged by research assistants.

Related Conditions & MeSH terms

• HIV Seropositivity
• Methamphetamine Abuse
• Opioid-Related Disorders
• Opioid-use Disorder
• Substance-Related Disorders

Intervention

Behavioral:
• High intensity contingency management
Participants receive 12 weeks of contingency management.
• Low intensity contingency management
Participants receive 6 weeks of contingency management and 6 weeks of group education.
• SMS reminders
Participants receive two daily SMS reminders plus one weekly self-monitoring assessment.
• Matrix only
Participants attend 12 weekly Matrix group counseling sessions.
• Matrix + Contingency management
Participants attend 12 weekly Matrix group counseling sessions plus 12 weeks of contingency management.

Locations

Country	Name	City	State
Vietnam	Hai Ba Trung methadone clinic	Hanoi
Vietnam	Long Bien methadone clinic	Hanoi
Vietnam	Nam Tu Liem Methadone clinic	Hanoi
Vietnam	District 4 Methadone clinic	Ho Chi Minh City

Sponsors (3)

Lead Sponsor	Collaborator
Hanoi Medical University	University of California, Los Angeles, University of Medicine and Pharmacy at Ho Chi Minh City

Country where clinical trial is conducted

Vietnam, 

References & Publications (163)

Al-Tayyib A, Koester S, Langegger S, Raville L. Heroin and Methamphetamine Injection: An Emerging Drug Use Pattern. Subst Use Misuse. 2017 Jul 3;52(8):1051-1058. doi: 10.1080/10826084.2016.1271432. Epub 2017 Mar 21. — View Citation

Alam-mehrjerdi Z, Mokri A, Dolan K. Methamphetamine use and treatment in Iran: A systematic review from the most populated Persian Gulf country. Asian J Psychiatr. 2015 Aug;16:17-25. doi: 10.1016/j.ajp.2015.05.036. Epub 2015 May 28. — View Citation

Almirall D, Nahum-Shani I, Sherwood NE, Murphy SA. Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research. Transl Behav Med. 2014 Sep;4(3):260-74. doi: 10.1007/s13142-014-0265-0. — View Citation

Amato L, Minozzi S, Davoli M, Vecchi S. Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence. Cochrane Database Syst Rev. 2011 Oct 5;(10):CD004147. doi: 10.1002/14651858.CD004147.pub4. — View Citation

Apostolopoulos Y, Lemke MK, Barry AE, Lich KH. Moving alcohol prevention research forward-Part I: introducing a complex systems paradigm. Addiction. 2018 Feb;113(2):353-362. doi: 10.1111/add.13955. Epub 2017 Aug 25. — View Citation

Aralis HJ, Shoptaw S, Brookmeyer R, Ragsdale A, Bolan R, Gorbach PM. Psychiatric Illness, Substance Use, and Viral Suppression Among HIV-Positive Men of Color Who Have Sex with Men in Los Angeles. AIDS Behav. 2018 Oct;22(10):3117-3129. doi: 10.1007/s10461-018-2055-z. — View Citation

Assanangkornchai S, Balthip Q, Edwards JG; assistance of the ASSIST-SBI Development Co-investigators. Implementing the Alcohol, Smoking, Substance Involvement Screening Test and linked brief intervention service in primary care in Thailand. J Public Health (Oxf). 2014 Sep;36(3):443-9. doi: 10.1093/pubmed/fdu011. Epub 2014 Feb 25. — View Citation

Baingana F, al'Absi M, Becker AE, Pringle B. Global research challenges and opportunities for mental health and substance-use disorders. Nature. 2015 Nov 19;527(7578):S172-7. doi: 10.1038/nature16032. — View Citation

Bao YP, Liu ZM, Li JH, Zhang RM, Hao W, Zhao M, Shi J, McGoogan JM, Lu L. Club drug use and associated high-risk sexual behaviour in six provinces in China. Addiction. 2015 Jan;110 Suppl 1:11-9. doi: 10.1111/add.12770. — View Citation

Baumeister SE, Gelberg L, Leake BD, Yacenda-Murphy J, Vahidi M, Andersen RM. Effect of a primary care based brief intervention trial among risky drug users on health-related quality of life. Drug Alcohol Depend. 2014 Sep 1;142:254-61. doi: 10.1016/j.drugalcdep.2014.06.034. Epub 2014 Jul 4. — View Citation

Belzer ME, MacDonell KK, Ghosh S, Naar S, McAvoy-Banerjea J, Gurung S, Cain D, Fan CA, Parsons JT. Adaptive Antiretroviral Therapy Adherence Interventions for Youth Living With HIV Through Text Message and Cell Phone Support With and Without Incentives: Protocol for a Sequential Multiple Assignment Randomized Trial (SMART). JMIR Res Protoc. 2018 Dec 20;7(12):e11183. doi: 10.2196/11183. — View Citation

Benishek LA, Dugosh KL, Kirby KC, Matejkowski J, Clements NT, Seymour BL, Festinger DS. Prize-based contingency management for the treatment of substance abusers: a meta-analysis. Addiction. 2014 Sep;109(9):1426-36. doi: 10.1111/add.12589. Epub 2014 May 23. — View Citation

Beyrer C, Razak MH, Jittiwutikarn J, Suriyanon V, Vongchak T, Srirak N, Kawichai S, Tovanabutra S, Rungruengthanakit K, Sawanpanyalert P, Sripaipan T, Celentano DD. Methamphetamine users in northern Thailand: changing demographics and risks for HIV and STD among treatment-seeking substance abusers. Int J STD AIDS. 2004 Oct;15(10):697-704. doi: 10.1177/095646240401501012. — View Citation

Bortolon CB, Moreira TC, Signor L, Guahyba BL, Figueiro LR, Ferigolo M, Barros HM. Six-Month Outcomes of a Randomized, Motivational Tele-intervention for Change in the Codependent Behavior of Family Members of Drug Users. Subst Use Misuse. 2017 Jan 28;52(2):164-174. doi: 10.1080/10826084.2016.1223134. Epub 2016 Oct 18. — View Citation

Bui HTM, Le GM, Mai AQ, Zablotska-Manos I, Maher L. Barriers to access and uptake of antiretroviral therapy among HIV-positive men who have sex with men in Hanoi, Vietnam: from HIV testing to treatment. Cult Health Sex. 2017 Aug;19(8):859-872. doi: 10.1080/13691058.2016.1269203. Epub 2017 Jan 19. — View Citation

Carrico AW, Cherenack EM, Roach ME, Riley ED, Oni O, Dilworth SE, Shoptaw S, Hunt P, Roy S, Pallikkuth S, Pahwa S. Substance-associated elevations in monocyte activation among methamphetamine users with treated HIV infection. AIDS. 2018 Mar 27;32(6):767-771. doi: 10.1097/QAD.0000000000001751. — View Citation

Carrico AW, Flentje A, Gruber VA, Woods WJ, Discepola MV, Dilworth SE, Neilands TB, Jain J, Siever MD. Community-based harm reduction substance abuse treatment with methamphetamine-using men who have sex with men. J Urban Health. 2014 Jun;91(3):555-67. doi: 10.1007/s11524-014-9870-y. — View Citation

Carrico AW, Flentje A, Kober K, Lee S, Hunt P, Riley ED, Shoptaw S, Flowers E, Dilworth SE, Pahwa S, Aouizerat BE. Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection. Brain Behav Immun. 2018 Jul;71:108-115. doi: 10.1016/j.bbi.2018.04.004. Epub 2018 Apr 18. — View Citation

Carrico AW, Jain J, Discepola MV, Olem D, Andrews R, Woods WJ, Neilands TB, Shoptaw S, Gomez W, Dilworth SE, Moskowitz JT. A community-engaged randomized controlled trial of an integrative intervention with HIV-positive, methamphetamine-using men who have sex with men. BMC Public Health. 2016 Jul 30;16:673. doi: 10.1186/s12889-016-3325-1. — View Citation

Carrico AW, Nil E, Sophal C, Stein E, Sokunny M, Yuthea N, Evans JL, Ngak S, Maher L, Page K. Behavioral interventions for Cambodian female entertainment and sex workers who use amphetamine-type stimulants. J Behav Med. 2016 Jun;39(3):502-10. doi: 10.1007/s10865-016-9713-2. Epub 2016 Jan 18. — View Citation

Carroll KM. Lost in translation? Moving contingency management and cognitive behavioral therapy into clinical practice. Ann N Y Acad Sci. 2014 Oct;1327(1):94-111. doi: 10.1111/nyas.12501. Epub 2014 Sep 9. — View Citation

Celentano DD, Sirirojn B, Sutcliffe CG, Quan VM, Thomson N, Keawvichit R, Wongworapat K, Latkin C, Taechareonkul S, Sherman SG, Aramrattana A. Sexually transmitted infections and sexual and substance use correlates among young adults in Chiang Mai, Thailand. Sex Transm Dis. 2008 Apr;35(4):400-5. doi: 10.1097/OLQ.0b013e31815fd412. — View Citation

Chen W, Hong Y, Zou X, McLaughlin MM, Xia Y, Ling L. Effectiveness of prize-based contingency management in a methadone maintenance program in China. Drug Alcohol Depend. 2013 Nov 1;133(1):270-4. doi: 10.1016/j.drugalcdep.2013.05.028. Epub 2013 Jul 4. — View Citation

Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, Wu AW. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care. 2000 Jun;12(3):255-66. doi: 10.1080/09540120050042891. — View Citation

Clatts MC, Goldsamt LA, Giang le M, Yu G. Sexual practices, partner concurrency and high rates of sexually transmissible infections among male sex workers in three cities in Vietnam. Sex Health. 2015 Mar;12(1):39-47. doi: 10.1071/SH14101. — View Citation

Clatts MC, Goldsamt LA, Giang LM, Quoc Bao L, Yu G, Colby D. Sexually transmissible infection and HIV prevention and treatment for young male sex workers in Vietnam: findings from the SHEATH intervention. Sex Health. 2016 Nov;13(6):575-581. doi: 10.1071/SH16051. — View Citation

Cohen A, Riley D, McGregor C. The Emergence of Methamphetamine in Thailand: Interventions and Treatment. In: Pates R, Riley D, editors. Interv Amphetamine Misuse. Oxford, UK: John Wiley & Sons; 2009. p. 159-172.

Colfax G, Santos GM, Chu P, Vittinghoff E, Pluddemann A, Kumar S, Hart C. Amphetamine-group substances and HIV. Lancet. 2010 Aug 7;376(9739):458-74. doi: 10.1016/S0140-6736(10)60753-2. — View Citation

Collins LM, Murphy SA, Bierman KL. A conceptual framework for adaptive preventive interventions. Prev Sci. 2004 Sep;5(3):185-96. doi: 10.1023/b:prev.0000037641.26017.00. — View Citation

Conners EE, Gaines TL, Strathdee SA, Magis-Rodriguez C, Brouwer KC. Structural factors associated with methamphetamine smoking among female sex workers in Tijuana, Mexico. Drug Alcohol Rev. 2018 Apr;37 Suppl 1(Suppl 1):S294-S302. doi: 10.1111/dar.12633. Epub 2017 Dec 7. — View Citation

Creswell JW. Designing and conducting mixed methods research. 2nd ed. Los Angeles: SAGE Publications; 2011

Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012 Mar;50(3):217-26. doi: 10.1097/MLR.0b013e3182408812. — View Citation

Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009 Aug 7;4:50. doi: 10.1186/1748-5908-4-50. — View Citation

Damschroder LJ, Hagedorn HJ. A guiding framework and approach for implementation research in substance use disorders treatment. Psychol Addict Behav. 2011 Jun;25(2):194-205. doi: 10.1037/a0022284. — View Citation

Daniulaityte R, Juhascik MP, Strayer KE, Sizemore IE, Zatreh M, Nahhas RW, Harshbarger KE, Antonides HM, Martins SS, Carlson RG. Trends in fentanyl and fentanyl analogue-related overdose deaths - Montgomery County, Ohio, 2015-2017. Drug Alcohol Depend. 2019 May 1;198:116-120. doi: 10.1016/j.drugalcdep.2019.01.045. Epub 2019 Mar 18. — View Citation

Degenhardt L, Mathers B, Guarinieri M, Panda S, Phillips B, Strathdee SA, Tyndall M, Wiessing L, Wodak A, Howard J; Reference Group to the United Nations on HIV and injecting drug use. Meth/amphetamine use and associated HIV: Implications for global policy and public health. Int J Drug Policy. 2010 Sep;21(5):347-58. doi: 10.1016/j.drugpo.2009.11.007. Epub 2010 Feb 1. — View Citation

Des Jarlais DC, Thi Huong D, Thi Hai Oanh K, Khue Pham M, Thi Giang H, Thi Tuyet Thanh N, Arasteh K, Feelemyer J, Hammett T, Peries M, Michel L, Vu Hai V, Roustide MJ, Moles JP, Laureillard D, Nagot N; DRIVE Study Team. Prospects for ending the HIV epidemic among persons who inject drugs in Haiphong, Vietnam. Int J Drug Policy. 2016 Jun;32:50-6. doi: 10.1016/j.drugpo.2016.02.021. Epub 2016 Feb 27. — View Citation

DiIorio C, Maibach E, O'Leary A, Sanderson CA, Celentano D. Measurement of condom use self-efficacy and outcome expectancies in a geographically diverse group of STD patients. AIDS Educ Prev. 1997 Feb;9(1):1-13. — View Citation

Dugosh K, Abraham A, Seymour B, McLoyd K, Chalk M, Festinger D. A Systematic Review on the Use of Psychosocial Interventions in Conjunction With Medications for the Treatment of Opioid Addiction. J Addict Med. 2016 Mar-Apr;10(2):93-103. doi: 10.1097/ADM.0000000000000193. — View Citation

Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry. 2008 Feb;165(2):179-87. doi: 10.1176/appi.ajp.2007.06111851. Epub 2008 Jan 15. — View Citation

Ellis MS, Kasper ZA, Cicero TJ. Twin epidemics: The surging rise of methamphetamine use in chronic opioid users. Drug Alcohol Depend. 2018 Dec 1;193:14-20. doi: 10.1016/j.drugalcdep.2018.08.029. Epub 2018 Oct 10. — View Citation

Feelemyer J, Duong Thi H, Khue Pham M, Hoang Thi G, Thi Tuyet Thanh N, Thi Hai Oanh K, Arasteh K, Moles JP, Vu Hai V, Vallo R, Quillet C, Rapoud D, Michel L, Hammett T, Laureillard D, Nagot N, Des Jarlais D; DRIVE Study Team. Increased Methamphetamine Use among Persons Who Inject Drugs in Hai Phong, Vietnam, and the Association with Injection and Sexual Risk Behaviors. J Psychoactive Drugs. 2018 Nov-Dec;50(5):382-389. doi: 10.1080/02791072.2018.1508790. Epub 2018 Sep 5. — View Citation

Feldman MB, Kepler KL, Irvine MK, Thomas JA. Associations between drug use patterns and viral load suppression among HIV-positive individuals who use support services in New York City. Drug Alcohol Depend. 2019 Apr 1;197:15-21. doi: 10.1016/j.drugalcdep.2018.12.015. Epub 2019 Jan 15. — View Citation

Galloway GP, Polcin D, Kielstein A, Brown M, Mendelson J. A nine session manual of motivational enhancement therapy for methamphetamine dependence: adherence and efficacy. J Psychoactive Drugs. 2007 Nov;Suppl 4:393-400. doi: 10.1080/02791072.2007.10399900. — View Citation

García-Aurrecoechea VR, Gutiérrez-López AD, Rodríguez-Kuri SE, Velázquez-Altamirano M, Fernández-Cáceres C. Increasing methamphetamine use trends alert among patients in Mexico. J Subst Use. 2018 Feb 5;0(0):1-6.

Garofalo R, Mustanski BS, McKirnan DJ, Herrick A, Donenberg GR. Methamphetamine and young men who have sex with men: understanding patterns and correlates of use and the association with HIV-related sexual risk. Arch Pediatr Adolesc Med. 2007 Jun;161(6):591-6. doi: 10.1001/archpedi.161.6.591. — View Citation

Gelberg L, Andersen RM, Afifi AA, Leake BD, Arangua L, Vahidi M, Singleton K, Yacenda-Murphy J, Shoptaw S, Fleming MF, Baumeister SE. Project QUIT (Quit Using Drugs Intervention Trial): a randomized controlled trial of a primary care-based multi-component brief intervention to reduce risky drug use. Addiction. 2015 Nov;110(11):1777-90. doi: 10.1111/add.12993. — View Citation

Giang L, Thuy D, Trang N, Okafor CN, Li M, Shoptaw S. Feasibility And Outcomes Of Evidence-Based Interventions To Reduce Methamphetamine Use Among Patients On Methadone Maintenance Therapy In Hanoi, Vietnam (Poster presentation at 2019 NIDA International Forum). San Antonio, Texas; 2019.

Giang L, Thuy D, Trang N, Okafor CN, Li M, Shoptaw S. Severity of methamphetamine use among methadone patients in Vietnam: Prevalence and correlates (Poster presentation at CPDD 81st Annual Scientific Meeting). San Antonio, Texas; 2019

Giang LM, Ngoc LB, Hoang VH, Mulvey K, Rawson RA. Substance use disorders and HIV in Vietnam since Doi Moi (Renovation): an overview. J Food Drug Anal. 2013 Dec;21(4):S42-S45. doi: 10.1016/j.jfda.2013.09.032. — View Citation

Gomicronmez W, Olem D, Andrews R, Discepola MV, Ambrose P, Dilworth SE, Carrico AW. Optimizing Contingency Management with Methamphetamine-Using Men who Have Sex with Men. Cogn Behav Pract. 2018 May;25(2):286-295. doi: 10.1016/j.cbpra.2017.08.003. Epub 2017 Sep 11. — View Citation

Gonzales R, Mooney L, Rawson RA. The methamphetamine problem in the United States. Annu Rev Public Health. 2010;31:385-98. doi: 10.1146/annurev.publhealth.012809.103600. — View Citation

Gouse H, Joska JA, Lion RR, Watt MH, Burnhams W, Carrico AW, Meade CS. HIV testing and sero-prevalence among methamphetamine users seeking substance abuse treatment in Cape Town. Drug Alcohol Rev. 2016 Sep;35(5):580-3. doi: 10.1111/dar.12371. Epub 2015 Dec 14. — View Citation

Grant S, Agniel D, Almirall D, Burkhart Q, Hunter SB, McCaffrey DF, Pedersen ER, Ramchand R, Griffin BA. Developing adaptive interventions for adolescent substance use treatment settings: protocol of an observational, mixed-methods project. Addict Sci Clin Pract. 2017 Dec 19;12(1):35. doi: 10.1186/s13722-017-0099-4. — View Citation

Green HD. A Community-Based Evaluation of Screening, Brief Intervention, and Referral to Treatment (SBIRT) for the Black Community. Qual Health Res. 2018 Feb;28(3):418-432. doi: 10.1177/1049732317746962. Epub 2017 Dec 18. — View Citation

Grov C, Rendina HJ, John SA, Parsons JT. Determining the Roles that Club Drugs, Marijuana, and Heavy Drinking Play in PrEP Medication Adherence Among Gay and Bisexual Men: Implications for Treatment and Research. AIDS Behav. 2019 May;23(5):1277-1286. doi: 10.1007/s10461-018-2309-9. — View Citation

Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, Bonsel G, Badia X. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011 Dec;20(10):1727-36. doi: 10.1007/s11136-011-9903-x. Epub 2011 Apr 9. — View Citation

Hintz J. PASS 12. Kaysville, Utah, USA: NCSS, LLC www.ncss.com; 2013.

Ho HT, Le GM, Dinh TT. Female sex workers who use amphetamine-type stimulants (ATS) in three cities of Vietnam: use and sexual risks related to HIV/AIDS. Glob Public Health. 2013;8(5):552-69. doi: 10.1080/17441692.2013.790459. Epub 2013 May 16. — View Citation

Hoang TV, Ha TT, Hoang TM, Nhu NT, Quoc NC, Tam Nt, Mills S. Impact of a methadone maintenance therapy pilot in Vietnam and its role in a scaled-up response. Harm Reduct J. 2015 Oct 16;12:39. doi: 10.1186/s12954-015-0075-9. — View Citation

Hojilla JC, Vlahov D, Glidden DV, Amico KR, Mehrotra M, Hance R, Grant RM, Carrico AW. Skating on thin ice: stimulant use and sub-optimal adherence to HIV pre-exposure prophylaxis. J Int AIDS Soc. 2018 Mar;21(3):e25103. doi: 10.1002/jia2.25103. — View Citation

Holloway IW, Tan D, Gildner JL, Beougher SC, Pulsipher C, Montoya JA, Plant A, Leibowitz A. Facilitators and Barriers to Pre-Exposure Prophylaxis Willingness Among Young Men Who Have Sex with Men Who Use Geosocial Networking Applications in California. AIDS Patient Care STDS. 2017 Dec;31(12):517-527. doi: 10.1089/apc.2017.0082. — View Citation

Hser YI, Li J, Jiang H, Zhang R, Du J, Zhang C, Zhang B, Evans E, Wu F, Chang YJ, Peng C, Huang D, Stitzer ML, Roll J, Zhao M. Effects of a randomized contingency management intervention on opiate abstinence and retention in methadone maintenance treatment in China. Addiction. 2011 Oct;106(10):1801-9. doi: 10.1111/j.1360-0443.2011.03490.x. Epub 2011 Jul 27. — View Citation

Huang YS, Tang TC, Lin CH, Yen CF. Effects of motivational enhancement therapy on readiness to change MDMA and methamphetamine use behaviors in Taiwanese adolescents. Subst Use Misuse. 2011;46(4):411-6. doi: 10.3109/10826084.2010.501664. Epub 2010 Aug 24. — View Citation

Jin H, Ogunbajo A, Mimiaga MJ, Duncan DT, Boyer E, Chai P, Dilworth SE, Carrico AW. Over the influence: The HIV care continuum among methamphetamine-using men who have sex with men. Drug Alcohol Depend. 2018 Nov 1;192:125-128. doi: 10.1016/j.drugalcdep.2018.07.038. Epub 2018 Sep 13. — View Citation

Khumsaen N, Stephenson R. Adaptation of the HIV/AIDS Self-Management Education Program for Men Who Have Sex With Men in Thailand: An Application of the ADAPT-ITT Framework. AIDS Educ Prev. 2017 Oct;29(5):401-417. doi: 10.1521/aeap.2017.29.5.401. — View Citation

Khuong LQ, Vu TT, Huynh VN, Thai TT. Psychometric properties of the medical outcomes study: social support survey among methadone maintenance patients in Ho Chi Minh City, Vietnam: a validation study. Subst Abuse Treat Prev Policy. 2018 Feb 14;13(1):8. doi: 10.1186/s13011-018-0147-4. — View Citation

Kirk MA, Kelley C, Yankey N, Birken SA, Abadie B, Damschroder L. A systematic review of the use of the Consolidated Framework for Implementation Research. Implement Sci. 2016 May 17;11:72. doi: 10.1186/s13012-016-0437-z. — View Citation

Korthuis PT, Bart G, Kunkel LE, Diep NB, Brinkerhoff C, Giang LM. Buprenorphine versus Methadone impact on the HIV care continuum in Vietnam: BRAVCO study 6-month outcomes (Poster presentation at 79th CPDD Annual Scientific Meeting). San Diego, CA; 2018.

Landovitz RJ, Desmond KA, Gildner JL, Leibowitz AA. Quality of Care for HIV/AIDS and for Primary Prevention by HIV Specialists and Nonspecialists. AIDS Patient Care STDS. 2016 Sep;30(9):395-408. doi: 10.1089/apc.2016.0170. — View Citation

Landovitz RJ, Fletcher JB, Inzhakova G, Lake JE, Shoptaw S, Reback CJ. A novel combination HIV prevention strategy: post-exposure prophylaxis with contingency management for substance abuse treatment among methamphetamine-using men who have sex with men. AIDS Patient Care STDS. 2012 Jun;26(6):320-8. doi: 10.1089/apc.2011.0432. — View Citation

Landovitz RJ, Fletcher JB, Shoptaw S, Reback CJ. Contingency management facilitates the use of postexposure prophylaxis among stimulant-using men who have sex with men. Open Forum Infect Dis. 2015 Jan 1;2(1):ofu114. doi: 10.1093/ofid/ofu114. eCollection 2015 Jan. — View Citation

Larsen DL, Attkisson CC, Hargreaves WA, Nguyen TD. Assessment of client/patient satisfaction: development of a general scale. Eval Program Plann. 1979;2(3):197-207. doi: 10.1016/0149-7189(79)90094-6. No abstract available. — View Citation

Lee NK, Rawson RA. A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev. 2008 May;27(3):309-17. doi: 10.1080/09595230801919494. — View Citation

Lei H, Nahum-Shani I, Lynch K, Oslin D, Murphy SA. A "SMART" design for building individualized treatment sequences. Annu Rev Clin Psychol. 2012;8:21-48. doi: 10.1146/annurev-clinpsy-032511-143152. Epub 2011 Dec 12. — View Citation

Li L, Hien NT, Lin C, Tuan NA, Tuan le A, Farmer SC, Detels R. An intervention to improve mental health and family well-being of injecting drug users and family members in Vietnam. Psychol Addict Behav. 2014 Jun;28(2):607-13. doi: 10.1037/a0033926. Epub 2013 Sep 30. — View Citation

Li L, Liang LJ, Lin C, Feng N, Cao W, Wu Z. An intervention to improve provider-patient interaction at methadone maintenance treatment in China. J Subst Abuse Treat. 2019 Apr;99:149-155. doi: 10.1016/j.jsat.2019.01.022. Epub 2019 Feb 3. — View Citation

Li L, Luo S, Lan CW, Lin C, Tuan LA, Feng N, Tuan NA. Alcohol Use, HIV Treatment Adherence, and Sexual Risk Among People with a History of Injecting Drug Use in Vietnam. AIDS Behav. 2017 Nov;21(Suppl 2):167-173. doi: 10.1007/s10461-017-1860-0. — View Citation

Li L, Tuan NA, Liang LJ, Lin C, Farmer SC, Flore M. Mental health and family relations among people who inject drugs and their family members in Vietnam. Int J Drug Policy. 2013 Nov;24(6):545-9. doi: 10.1016/j.drugpo.2013.06.007. Epub 2013 Aug 1. — View Citation

Li L, Wu Z, Cao X, Zhang L. Provider-Client Interaction in Methadone Treatment Clinics in China. J Drug Issues. 2012 Apr 1;42(2):10.1177/0022042612446593. doi: 10.1177/0022042612446593. — View Citation

Liao M, Kang D, Tao X, Li J, Qian Y, Wang G, Jiang B, Bi Z, Jia Y. Dual epidemics of syphilis and methamphetamine use among drug users in Shandong Province of China. AIDS Care. 2013;25(10):1236-44. doi: 10.1080/09540121.2013.764384. Epub 2013 Feb 11. — View Citation

Lin C, Wu Z, Detels R. Opiate users' perceived barriers against attending methadone maintenance therapy: a qualitative study in China. Subst Use Misuse. 2011;46(9):1190-8. doi: 10.3109/10826084.2011.561905. Epub 2011 Mar 21. — View Citation

Liu D, Gu J, Xu H, Hao C, Jiao M, Zhang X, Zhao Y, Andrew B, Hao Y. Club drugs and alcohol abuse predicted dropout and poor adherence among methadone maintenance treatment patients in Guangzhou, China. AIDS Care. 2017 Apr;29(4):458-463. doi: 10.1080/09540121.2016.1259452. Epub 2016 Nov 30. — View Citation

Liu D, Jiang Z, Xiu C, Li Z, Song Q, Wang Z. Sexually transmitted infection prevalence and related risk factors among heterosexual male methamphetamine users in China. Int J STD AIDS. 2017 Oct;28(12):1208-1214. doi: 10.1177/0956462417693165. Epub 2017 Feb 8. — View Citation

Luoma JB, Nobles RH, Drake CE, Hayes SC, O'Hair A, Fletcher L, Kohlenberg BS. Self-Stigma in Substance Abuse: Development of a New Measure. J Psychopathol Behav Assess. 2013 Jun 1;35(2):223-234. doi: 10.1007/s10862-012-9323-4. — View Citation

Magidson JF, Gouse H, Burnhams W, Wu CY, Myers B, Joska JA, Carrico AW. Beyond methamphetamine: Documenting the implementation of the Matrix model of substance use treatment for opioid users in a South African setting. Addict Behav. 2017 Mar;66:132-137. doi: 10.1016/j.addbeh.2016.11.014. Epub 2016 Nov 17. — View Citation

Magill M, Ray LA. Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials. J Stud Alcohol Drugs. 2009 Jul;70(4):516-27. doi: 10.15288/jsad.2009.70.516. — View Citation

Martin GW, Wilkinson DA, Poulos CX. The Drug Avoidance Self-Efficacy Scale. J Subst Abuse. 1995;7(2):151-63. doi: 10.1016/0899-3289(95)90001-2. — View Citation

McGregor C, Srisurapanont M, Mitchell A, Longo MC, Cahill S, White JM. Psychometric evaluation of the Amphetamine Cessation Symptom Assessment. J Subst Abuse Treat. 2008 Jun;34(4):443-9. doi: 10.1016/j.jsat.2007.05.007. Epub 2007 Jul 13. — View Citation

McLellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G, Pettinati H, Argeriou M. The Fifth Edition of the Addiction Severity Index. J Subst Abuse Treat. 1992;9(3):199-213. doi: 10.1016/0740-5472(92)90062-s. — View Citation

Menza TW, Jameson DR, Hughes JP, Colfax GN, Shoptaw S, Golden MR. Contingency management to reduce methamphetamine use and sexual risk among men who have sex with men: a randomized controlled trial. BMC Public Health. 2010 Dec 20;10:774. doi: 10.1186/1471-2458-10-774. — View Citation

Miller WR, Tonigan JS. Assessing drinkers' motivation for change: The Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES). Psychol Addict Behav. 19960101;10(2):81.

Mimiaga MJ, Kuhns LM, Biello KB, Olson J, Hoehnle S, Santostefano CM, Hughto JMW, Safi H, Salhaney P, Chen D, Garofalo R. Positive STEPS - a randomized controlled efficacy trial of an adaptive intervention for strengthening adherence to antiretroviral HIV treatment among youth: study protocol. BMC Public Health. 2018 Jul 13;18(1):867. doi: 10.1186/s12889-018-5815-9. — View Citation

Moore DJ, Blackstone K, Woods SP, Ellis RJ, Atkinson JH, Heaton RK, Grant I; Hnrc Group And The Tmarc Group. Methamphetamine use and neuropsychiatric factors are associated with antiretroviral non-adherence. AIDS Care. 2012;24(12):1504-13. doi: 10.1080/09540121.2012.672718. Epub 2012 Apr 24. — View Citation

Morris K, Parry C. South African methamphetamine boom could fuel further HIV. Lancet Infect Dis. 2006 Aug;6(8):471. doi: 10.1016/s1473-3099(06)70539-4. No abstract available. — View Citation

Muhr T. Atlas.ti. Berlin: Scientific Software Development; 1997.

Nahum-Shani I, Qian M, Almirall D, Pelham WE, Gnagy B, Fabiano GA, Waxmonsky JG, Yu J, Murphy SA. Experimental design and primary data analysis methods for comparing adaptive interventions. Psychol Methods. 2012 Dec;17(4):457-477. doi: 10.1037/a0029372. Epub 2012 Oct 1. — View Citation

Nerlander LMC, Hoots BE, Bradley H, Broz D, Thorson A, Paz-Bailey G; NHBS Group. HIV infection among MSM who inject methamphetamine in 8 US cities. Drug Alcohol Depend. 2018 Sep 1;190:216-223. doi: 10.1016/j.drugalcdep.2018.06.017. Epub 2018 Jul 20. — View Citation

Neumann PJ, Sanders GD, Russell LB, Siegel JE, Ganiats TG, editors. Cost effectiveness in health and medicine. Second edition. Oxford ; New York: Oxford University Press; 2017.

Nguyen Bich D, Korthuis PT, Nguyen Thu T, Van Dinh H, Le Minh G. HIV Patients' Preference for Integrated Models of Addiction and HIV Treatment in Vietnam. J Subst Abuse Treat. 2016 Oct;69:57-63. doi: 10.1016/j.jsat.2016.07.003. Epub 2016 Jul 19. — View Citation

Nguyen Huu C, Kieu Cong T. Application of Matrix model in support of trreatment and recovery for ATS dependents (Nghiên c?u s? d?ng li?u pháp tâm lý Matrix trong h? tr? di?u tr? nghi?n và ph?c h?i ch?c nang cho ngu?i nghi?n ma túy t?ng h?p d?ng amphetamine). Conference Presentation presented at: Treatment Approaches for ATS Dependence; 2016 Dec 20; Hanoi, Vietnam

Nguyen TT, Luong AN, Nham TTT, Chauvin C, Feelemyer J, Nagot N, Jarlais DD, Le MG, Jauffret-Roustide M. Struggling to achieve a 'normal life': A qualitative study of Vietnamese methadone patients. Int J Drug Policy. 2019 Jun;68:18-26. doi: 10.1016/j.drugpo.2019.03.026. Epub 2019 Apr 9. — View Citation

Nguyen TT, Nguyen LT, Pham MD, Vu HH, Mulvey KP. Methadone maintenance therapy in Vietnam: an overview and scaling-up plan. Adv Prev Med. 2012;2012:732484. doi: 10.1155/2012/732484. Epub 2012 Nov 25. — View Citation

NIDA. Seek, Test, Treat and Retain: Addressing HIV among Vulnerable Populations [Internet]. 2013 [cited 2018 Nov 15]. Available from: https://www.drugabuse.gov/researchers/research-resources/data-harmonization-projects/seek-test-treat-retain/addressing-hiv-among-vulnerable-populations

O'Donnell A, Anderson P, Newbury-Birch D, Schulte B, Schmidt C, Reimer J, Kaner E. The impact of brief alcohol interventions in primary healthcare: a systematic review of reviews. Alcohol Alcohol. 2014 Jan-Feb;49(1):66-78. doi: 10.1093/alcalc/agt170. Epub 2013 Nov 13. — View Citation

Parsons JT, John SA, Millar BM, Starks TJ. Testing the Efficacy of Combined Motivational Interviewing and Cognitive Behavioral Skills Training to Reduce Methamphetamine Use and Improve HIV Medication Adherence Among HIV-Positive Gay and Bisexual Men. AIDS Behav. 2018 Aug;22(8):2674-2686. doi: 10.1007/s10461-018-2086-5. — View Citation

Petersen I, Evans-Lacko S, Semrau M, Barry MM, Chisholm D, Gronholm P, Egbe CO, Thornicroft G. Promotion, prevention and protection: interventions at the population- and community-levels for mental, neurological and substance use disorders in low- and middle-income countries. Int J Ment Health Syst. 2016 Apr 11;10:30. doi: 10.1186/s13033-016-0060-z. eCollection 2016. — View Citation

Pollack TM, Duong HT, Pham TT, Nguyen TD, Libman H, Ngo L, McMahon JH, Elliott JH, Do CD, Colby DJ. Routine versus Targeted Viral Load Strategy among Patients Starting Antiretroviral in Hanoi, Vietnam. J Int AIDS Soc. 2019 Mar;22(3):e25258. doi: 10.1002/jia2.25258. — View Citation

Prendergast M, Podus D, Finney J, Greenwell L, Roll J. Contingency management for treatment of substance use disorders: a meta-analysis. Addiction. 2006 Nov;101(11):1546-60. doi: 10.1111/j.1360-0443.2006.01581.x. — View Citation

Prybylski D, Manopaiboon C, Visavakum P, Yongvanitjit K, Aramrattana A, Manomaipiboon P, Tanpradech S, Suksripanich O, Pattanasin S, Wolfe M, Whitehead SJ. Diverse HIV epidemics among people who inject drugs in Thailand: evidence from respondent-driven sampling surveys in Bangkok and Chiang Mai. Drug Alcohol Depend. 2015 Mar 1;148:126-35. doi: 10.1016/j.drugalcdep.2014.12.034. Epub 2015 Jan 12. — View Citation

Rajasingham R, Mimiaga MJ, White JM, Pinkston MM, Baden RP, Mitty JA. A systematic review of behavioral and treatment outcome studies among HIV-infected men who have sex with men who abuse crystal methamphetamine. AIDS Patient Care STDS. 2012 Jan;26(1):36-52. doi: 10.1089/apc.2011.0153. Epub 2011 Nov 9. — View Citation

Rawson RA, Huber A, McCann M, Shoptaw S, Farabee D, Reiber C, Ling W. A comparison of contingency management and cognitive-behavioral approaches during methadone maintenance treatment for cocaine dependence. Arch Gen Psychiatry. 2002 Sep;59(9):817-24. doi: 10.1001/archpsyc.59.9.817. — View Citation

Rawson RA, Marinelli-Casey P, Anglin MD, Dickow A, Frazier Y, Gallagher C, Galloway GP, Herrell J, Huber A, McCann MJ, Obert J, Pennell S, Reiber C, Vandersloot D, Zweben J; Methamphetamine Treatment Project Corporate Authors. A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence. Addiction. 2004 Jun;99(6):708-17. doi: 10.1111/j.1360-0443.2004.00707.x. — View Citation

Rawson RA, McCann MJ, Flammino F, Shoptaw S, Miotto K, Reiber C, Ling W. A comparison of contingency management and cognitive-behavioral approaches for stimulant-dependent individuals. Addiction. 2006 Feb;101(2):267-74. doi: 10.1111/j.1360-0443.2006.01312.x. — View Citation

Reback CJ, Fletcher JB, Leibowitz AA. Cost effectiveness of text messages to reduce methamphetamine use and HIV sexual risk behaviors among men who have sex with men. J Subst Abuse Treat. 2019 May;100:59-63. doi: 10.1016/j.jsat.2019.02.006. Epub 2019 Feb 27. — View Citation

Reback CJ, Fletcher JB, Shoptaw S, Mansergh G. Exposure to Theory-Driven Text Messages is Associated with HIV Risk Reduction Among Methamphetamine-Using Men Who have Sex with Men. AIDS Behav. 2015 Jun;19 Suppl 2:130-41. doi: 10.1007/s10461-014-0985-7. — View Citation

Reback CJ, Fletcher JB, Swendeman DA, Metzner M. Theory-Based Text-Messaging to Reduce Methamphetamine Use and HIV Sexual Risk Behaviors Among Men Who Have Sex with Men: Automated Unidirectional Delivery Outperforms Bidirectional Peer Interactive Delivery. AIDS Behav. 2019 Jan;23(1):37-47. doi: 10.1007/s10461-018-2225-z. — View Citation

Reback CJ, Ling D, Shoptaw S, Rohde J. Developing a Text Messaging Risk Reduction Intervention for Methamphetamine-Using MSM: Research Note. Open AIDS J. 2010 May 14;4:116-22. doi: 10.2174/1874613601004030116. — View Citation

Reback CJ, Peck JA, Dierst-Davies R, Nuno M, Kamien JB, Amass L. Contingency management among homeless, out-of-treatment men who have sex with men. J Subst Abuse Treat. 2010 Oct;39(3):255-63. doi: 10.1016/j.jsat.2010.06.007. Epub 2010 Jul 29. — View Citation

Reback CJ, Shoptaw S, Riley J, Stone K. Getting Off: A Behavioral Treatment Intervention for Gay and Bisexual Methamphetamine Users. A Training Manual for Counselors [Internet]. 2008 [cited 2017 Mar 31]. Available from: http://friendscommunitycenter.org/documents/Getting_Off_Counselor_Training_Manual.pdf

Reback CJ, Shoptaw S. Development of an evidence-based, gay-specific cognitive behavioral therapy intervention for methamphetamine-abusing gay and bisexual men. Addict Behav. 2014 Aug;39(8):1286-91. doi: 10.1016/j.addbeh.2011.11.029. Epub 2011 Nov 26. — View Citation

Reback CJ, Veniegas R, Shoptaw S. Getting Off: development of a model program for gay and bisexual male methamphetamine users. J Homosex. 2014;61(4):540-53. doi: 10.1080/00918369.2014.865459. — View Citation

Robles F. Meth, the Forgotten Killer, Is Back. And It's Everywhere. N Y Times [Internet]. 2018 Feb 15 [cited 2019 Apr 28]; Available from: https://www.nytimes.com/2018/02/13/us/meth-crystal-drug.html

Roux P, Lions C, Vilotitch A, Michel L, Mora M, Maradan G, Marcellin F, Spire B, Morel A, Carrieri PM; ANRS Methaville study group. Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm Reduct J. 2016 Apr 5;13:12. doi: 10.1186/s12954-016-0100-7. — View Citation

Saghaei M. Random allocation software for parallel group randomized trials. BMC Med Res Methodol. 2004 Nov 9;4:26. doi: 10.1186/1471-2288-4-26. — View Citation

Sarason IG, Levine HM, Basham RB, Sarason BR. Assessing social support: The social support questionnaire. J Pers Soc Psychol. 1983;139.

Shariatirad S, Maarefvand M, Ekhtiari H. Methamphetamine use and methadone maintenance treatment: an emerging problem in the drug addiction treatment network in Iran. Int J Drug Policy. 2013 Nov;24(6):e115-6. doi: 10.1016/j.drugpo.2013.05.003. Epub 2013 Jun 15. No abstract available. — View Citation

Sherbourne CD, Stewart AL. The MOS social support survey. Soc Sci Med. 1991;32(6):705-14. doi: 10.1016/0277-9536(91)90150-b. — View Citation

Shoptaw S, Klausner JD, Reback CJ, Tierney S, Stansell J, Hare CB, Gibson S, Siever M, King WD, Kao U, Dang J. A public health response to the methamphetamine epidemic: the implementation of contingency management to treat methamphetamine dependence. BMC Public Health. 2006 Aug 18;6:214. doi: 10.1186/1471-2458-6-214. — View Citation

Shoptaw S, Landovitz RJ, Reback CJ. Contingent Vs. Non-Contingent Rewards: Time-Based Intervention Response Patterns Among Stimulant-Using Men Who Have Sex With Men. J Subst Abuse Treat. 2017 Jan;72:19-24. doi: 10.1016/j.jsat.2016.09.004. Epub 2016 Sep 13. — View Citation

Shoptaw S, Reback C, Peck JA, Larkins S, Freese TE, Rawson RA. Getting Off: A Behavioral Treatment Intervention for Gay and Bisexual Methamphetamine Users [Internet]. 2005 [cited 2017 Mar 31]. Available from: http://friendscommunitycenter.org/documents/Getting_Off_Treatment_Manual.pdf

Shoptaw S, Reback CJ, Larkins S, Wang PC, Rotheram-Fuller E, Dang J, Yang X. Outcomes using two tailored behavioral treatments for substance abuse in urban gay and bisexual men. J Subst Abuse Treat. 2008 Oct;35(3):285-93. doi: 10.1016/j.jsat.2007.11.004. Epub 2008 Mar 7. — View Citation

Shoptaw S, Reback CJ, Peck JA, Yang X, Rotheram-Fuller E, Larkins S, Veniegas RC, Freese TE, Hucks-Ortiz C. Behavioral treatment approaches for methamphetamine dependence and HIV-related sexual risk behaviors among urban gay and bisexual men. Drug Alcohol Depend. 2005 May 9;78(2):125-34. doi: 10.1016/j.drugalcdep.2004.10.004. Epub 2004 Nov 28. — View Citation

Shoptaw S, Reback CJ. Methamphetamine use and infectious disease-related behaviors in men who have sex with men: implications for interventions. Addiction. 2007 Apr;102 Suppl 1:130-5. doi: 10.1111/j.1360-0443.2006.01775.x. — View Citation

Shoptaw S, Watson DW, Reiber C, Rawson RA, Montgomery MA, Majewska MD, Ling W. Randomized controlled pilot trial of cabergoline, hydergine and levodopa/carbidopa: Los Angeles Cocaine Rapid Efficacy Screening Trial (CREST). Addiction. 2005 Mar;100 Suppl 1:78-90. doi: 10.1111/j.1360-0443.2005.00991.x. — View Citation

Sorensen JL, Kosten T. Developing the tools of implementation science in substance use disorders treatment: applications of the consolidated framework for implementation research. Psychol Addict Behav. 2011 Jun;25(2):262-8. doi: 10.1037/a0022765. — View Citation

Sorsdahl K, Myers B, Ward C, Matzopoulos R, Mtukushe B, Nicol A, Stein DJ. Screening and brief interventions for substance use in emergency departments in the Western Cape province of South Africa: views of health care professionals. Int J Inj Contr Saf Promot. 2014;21(3):236-43. doi: 10.1080/17457300.2013.811267. Epub 2013 Jul 9. — View Citation

Strathdee SA, Stockman JK. Epidemiology of HIV among injecting and non-injecting drug users: current trends and implications for interventions. Curr HIV/AIDS Rep. 2010 May;7(2):99-106. doi: 10.1007/s11904-010-0043-7. — View Citation

Thai TT, Jones MK, Harris LM, Heard RC, Hills NK, Lindan CP. Symptoms of Depression in People Living with HIV in Ho Chi Minh City, Vietnam: Prevalence and Associated Factors. AIDS Behav. 2018 Jul;22(Suppl 1):76-84. doi: 10.1007/s10461-017-1946-8. — View Citation

Thai TT, Jones MK, Harris LM, Heard RC. Prevalence and Correlates of Probable HIV-Associated Dementia in HIV Outpatients in Ho Chi Minh City, Vietnam. J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):366-375. doi: 10.1177/2325957417701195. Epub 2017 Apr 3. — View Citation

Thai TT, Jones MK, Harris LM, Heard RC. The association between symptoms of mental disorders and health risk behaviours in Vietnamese HIV positive outpatients: a cross-sectional study. BMC Public Health. 2017 Mar 14;17(1):250. doi: 10.1186/s12889-017-4162-6. — View Citation

Twitchell GR, Huber A, Reback CJ, Shoptaw S. Comparison of General and Detailed HIV Risk Assessments Among Methamphetamine Abusers. AIDS Behav. 2002 Jun 1;6(2):153-162.

UNAIDS. Costing Guidelines for HIV Prevention Strategies. UNAIDS (Geneva); 2000 p. 140.

UNODC. The Challenge of Synthetic Drugs in East and South-East Asia and Oceania: Trends and Patterns of Amphetamine-type Stimulants and New Psychoactive Substances. Vienna, Austria: United Nations Office on Drugs and Crime; 2015 May.

UNODC. World Drug Report 2018. Vienna, Austria: United Nations Ofice on Drugs and Crime; 2018

VanDevanter N, Kumar P, Nguyen N, Nguyen L, Nguyen T, Stillman F, Weiner B, Shelley D. Application of the Consolidated Framework for Implementation Research to assess factors that may influence implementation of tobacco use treatment guidelines in the Viet Nam public health care delivery system. Implement Sci. 2017 Feb 28;12(1):27. doi: 10.1186/s13012-017-0558-z. — View Citation

Vietnam Ministry of Health. Báo cáo Ðánh giá và t?ng k?t 10 nam tri?n khai chuong trình di?u tr? nghi?n các ch?t d?ng thu?c phi?n b?ng thu?c Methadone (Assessment and Review of 10 Years of Methadone Maintenance Therapy in Vietnam: Report to the Prime Minister) (DRAFT). Vietnam Ministry of Health; n.d.

Vu NT, Holt M, Phan HT, La LT, Tran GM, Doan TT, Nguyen TN, de Wit J. The Relationship Between Methamphetamine Use, Sexual Sensation Seeking and Condomless Anal Intercourse Among Men Who Have Sex With Men in Vietnam: Results of a Community-Based, Cross-Sectional Study. AIDS Behav. 2017 Apr;21(4):1105-1116. doi: 10.1007/s10461-016-1467-x. — View Citation

Vuong T, Nguyen N, Le G, Shanahan M, Ali R, Ritter A. The political and scientific challenges in evaluating compulsory drug treatment centers in Southeast Asia. Harm Reduct J. 2017 Jan 11;14(1):2. doi: 10.1186/s12954-016-0130-1. — View Citation

Vuong T, Ritter A, Shanahan M, Ali R, Nguyen N, Pham K, Vuong TTA, Le GM. Outcomes of compulsory detention compared to community-based voluntary methadone maintenance treatment in Vietnam. J Subst Abuse Treat. 2018 Apr;87:9-15. doi: 10.1016/j.jsat.2018.01.011. Epub 2018 Jan 16. — View Citation

Vuong T, Shanahan M, Nguyen N, Le G, Ali R, Pham K, Vuong TTA, Dinh T, Ritter A. Cost-effectiveness of center-based compulsory rehabilitation compared to community-based voluntary methadone maintenance treatment in Hai Phong City, Vietnam. Drug Alcohol Depend. 2016 Nov 1;168:147-155. doi: 10.1016/j.drugalcdep.2016.09.008. Epub 2016 Sep 13. — View Citation

Wang R, Ding Y, Bai H, Duan S, Ye R, Yang Y, Wang J, Tang R, Gao M, He N. Illicit Heroin and Methamphetamine Use among Methadone Maintenance Treatment Patients in Dehong Prefecture of Yunnan Province, China. PLoS One. 2015 Jul 21;10(7):e0133431. doi: 10.1371/journal.pone.0133431. eCollection 2015. — View Citation

Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83. — View Citation

Watt MH, Meade CS, Kimani S, MacFarlane JC, Choi KW, Skinner D, Pieterse D, Kalichman SC, Sikkema KJ. The impact of methamphetamine ("tik") on a peri-urban community in Cape Town, South Africa. Int J Drug Policy. 2014 Mar;25(2):219-25. doi: 10.1016/j.drugpo.2013.10.007. Epub 2013 Oct 26. — View Citation

Wechsberg WM, Luseno WK, Karg RS, Young S, Rodman N, Myers B, Parry CD. Alcohol, cannabis, and methamphetamine use and other risk behaviours among Black and Coloured South African women: a small randomized trial in the Western Cape. Int J Drug Policy. 2008 Apr;19(2):130-9. doi: 10.1016/j.drugpo.2007.11.018. Epub 2008 Jan 18. — View Citation

Willer B, Ottenbacher KJ, Coad ML. The community integration questionnaire. A comparative examination. Am J Phys Med Rehabil. 1994 Apr;73(2):103-11. doi: 10.1097/00002060-199404000-00006. — View Citation

Wingood GM, DiClemente RJ. The ADAPT-ITT model: a novel method of adapting evidence-based HIV Interventions. J Acquir Immune Defic Syndr. 2008 Mar 1;47 Suppl 1:S40-6. doi: 10.1097/QAI.0b013e3181605df1. — View Citation

Worley MJ, Swanson A-N, Heinzerling KG, Roche DJ, Shoptaw S. Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study. Drug Alcohol Depend. 2016 May 1;162:245-50. doi: 10.1016/j.drugalcdep.2016.02.036. Epub 2016 Mar 3. Erratum In: Drug Alcohol Depend. 2018 Sep 1;190:120. — View Citation

Wu H, Xiu C, Fu X, Li M, Wang Z, Li X, Wu J, Vermund SH, Hu Y. Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case-control study in China. Sex Transm Infect. 2019 Jun;95(4):267-272. doi: 10.1136/sextrans-2018-053878. Epub 2019 Mar 6. — View Citation

Young MM, Stevens A, Porath-Waller A, Pirie T, Garritty C, Skidmore B, Turner L, Arratoon C, Haley N, Leslie K, Reardon R, Sproule B, Grimshaw J, Moher D. Effectiveness of brief interventions as part of the screening, brief intervention and referral to treatment (SBIRT) model for reducing the non-medical use of psychoactive substances: a systematic review protocol. Syst Rev. 2012 May 7;1:22. doi: 10.1186/2046-4053-1-22. — View Citation

Yu G, Clatts MC, Goldsamt LA, Giang le M. Substance use among male sex workers in Vietnam: prevalence, onset, and interactions with sexual risk. Int J Drug Policy. 2015 May;26(5):516-21. doi: 10.1016/j.drugpo.2014.10.011. Epub 2014 Nov 8. — View Citation

Zhang C, Liu Y, Sun X, Wang J, Lu HY, He X, Zhang H, Ruan YH, Shao Y, Vermund SH, Qian HZ. Substance use and HIV-risk behaviors among HIV-positive men who have sex with men in China: repeated measures in a cohort study design. AIDS Care. 2017 May;29(5):644-653. doi: 10.1080/09540121.2016.1255709. Epub 2016 Nov 10. — View Citation

ZUNG WW. A SELF-RATING DEPRESSION SCALE. Arch Gen Psychiatry. 1965 Jan;12:63-70. doi: 10.1001/archpsyc.1965.01720310065008. No abstract available. — View Citation

* Note: There are 163 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Increase in HIV viral suppression for HIV-positive participants	We will conduct quick HIV testing during screening and viral load test at baseline, 12, 24 and 48 weeks after enrolment.	48 weeks
Primary	Reduction in HIV risk behaviors for both HIV-positive and HIV-negative participants	Structured questionnaires will collect self-reported data at baseline, 24 and 48 weeks after enrolment	48 weeks
Primary	Reduction in methamphetamine use	This outcome is measured by urine test (point abstinence) and self-report (continuous abstinence and longest period). Urine tests will be collected just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th. Self-reported drug use information is collected at baseline, weeks 12th, 24th and 48th. We use one scale: Amphetamine Cessation Symptoms Assessment (ACSA), score range: 0-64, higher scores mean more severe symptoms.	48 weeks
Secondary	Adherence to ART if HIV-positive	This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.	48 weeks
Secondary	Frequency of HIV testing if HIV-negative	This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.	48 weeks
Secondary	Frequency of heroin use	This outcome will be measured by urine drug tests just before enrolment, twice a week during weeks of contingency management, group education and Matrix meetings, once a week during weeks of SMS reminders intervention, twice a week during week 12th, 24th, 48th.	48 weeks
Secondary	Frequency of opioid overdose	This information will be collected using the study questionnaire at baseline, weeks 12th, 24th and 48th.	48 weeks
Secondary	Changes in quality of life	This outcome will be measured using the study questionnaire at baseline, weeks 12th, 24th and 48th. We use the EQ-5D-5L scale (the 5-level, 5-dimension instrument developed by EuroQol Group in 2009). The Vietnam values range from -0.515 to 1. Higher scores mean worse quality of life.	48 weeks