Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03842137 |
Other study ID # |
1810-001 |
Secondary ID |
UG3DA047793 |
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
June 4, 2019 |
Est. completion date |
August 31, 2023 |
Study information
Verified date |
October 2023 |
Source |
Butler Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
In the current proposal, the investigators will measure behavioral and brain responses
following transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal
cortex (DLPFC) (anode on right DLPFC, cathode on the left DLPFC) delivered during cognitive
control network (CCN) priming. Participants with opioid dependence, in the first month of
prescribed buprenorphine or methadone, will be assessed twice using functional magnetic
resonance imaging (FMRI) and electroencephalographic (EEG), once prior to tDCS+CCN priming
and again at the completion of 5 sessions of tDCS+CCN priming (one week later). Task-based
and resting state functional connectivity will be used to examine networks associated with
craving (CR) and cognitive control. In Phase 1, FMRI and EEG will provide validation of
expected changes in these networks following tDCS stimulation of the DLPFC. In phase 2, the
investigators will perform a larger randomized clinical trial (RCT) (vs. sham control) to
address long-term neurobehavioral outcomes, including opioid relapse, craving, and sustained
FMRI changes.
Description:
This study has two phases. In phase one (UG3), the investigators propose to use FMRI to
quantify changes in brain function and EEG to examine oscillatory brain changes as well as
self-reported craving before and after administration of five sessions of tDCS+Cognitive
Control Network (CCN) priming stimulation vs. sham tDCS+CCN priming (randomized control
trial) in 60 opioid dependent participants who recently initiated buprenorphine or methadone.
Participants in the first month of prescribed buprenorphine or methadone will be assessed
using FMRI and EEG, once prior to tDCS and again one week later after completion of 5
sessions of tDCS+CCN priming. With a focus on the craving outcome, the investigators will use
two task-based FMRI paradigms that challenge networks associated with craving (CR) and
cognitive control (CCN), and will examine these and the salience network using resting state
functional connectivity. In Phase 1, FMRI and EEG will be expected to provide 1) validation
of expected network and oscillatory changes from tDCS-targeting and 2) an effect size for
DLPFC vs sham stimulation. Go/no go criteria for the UG3 phase will be demonstration of
greater FMRI change in any node of the CR or CCN networks or enhanced frontal theta power
during a WM task AND greater change (at least 10% difference between conditions, controlling
for baseline craving) in subjective craving measured during a cue reactivity task or outside
the FMRI following the tDCS+CCN priming intervention compared to sham tDCS+CCN priming.
In phase 2, the investigators will perform a larger RCT using the same treatment protocol in
100 opioid dependent participants who recently initiated buprenorphine or methadone.
Participants will be randomized to receive five sessions of tDCS+CCN priming stimulation vs.
sham tDCS+CCN priming. Phase two will address long-term (3-month) neurobehavioral outcomes,
including opioid relapse, craving, and sustained fMRI changes during a paradigm that
challenges networks associated with craving (CR) and cognitive control (CCN). During the 12
weeks of buprenorphine or methadone maintenance treatment, the investigators will examine our
primary clinical outcome, relapse (opioid use on >4 days per month and having an opioid
positive urine screen), as well as days of opioid use.