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Opiate Addiction clinical trials

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NCT ID: NCT03831113 Terminated - Pregnancy Clinical Trials

Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy

Start date: April 13, 2019
Phase: Phase 2
Study type: Interventional

This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes. Strategies to reduce opioid exposure will be explored.

NCT ID: NCT03583138 Completed - Clinical trials for Human Immunodeficiency Virus

HIV, Buprenorphine, and the Criminal Justice System (STRIDE2)

Start date: June 23, 2014
Phase:
Study type: Observational

STRIDE2 is a longitudinal, non-randomized study of individuals living with HIV who are dependent on opioids. This study is funded by the National Institute on Drug Abuse (R01DA030768, Altice, PI; Taxman & Lawson, Co-PIs) and is being conducted by George Mason University, Yale University, and Howard University.

NCT ID: NCT03278496 Completed - Opiate Addiction Clinical Trials

Recovery Housing and Drug Abuse Treatment Outcome

Start date: April 2001
Phase: N/A
Study type: Interventional

Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for recovery housing in the community. It is meant to provide motivation for continued abstinence while enhancing social stability. In this study, treatment was offered to inner city opiate and cocaine users immediately following a brief medically-supported residential detoxification. Previous research had shown that RBT produces 3- month outcomes superior to those for patients who are referred to outpatient treatment in the community. The present study compared outcomes for patients (N = 243) randomly assigned to receive abstinence-contingent recovery housing with (full RBT) or without additional intensive counseling or to receive usual care referral to outpatient treatment following detoxification. Outcomes were similar at 3- and 6-month follow-ups for those who received recovery housing with (full RBT) and without additional counseling and both these treatments were superior to usual care referral. Study findings support the efficacy of post-detoxification recovery housing with or without counseling for opiate and cocaine users.

NCT ID: NCT03150173 Completed - Opiate Addiction Clinical Trials

Onsite Buprenorphine Treatment at Syringe Exchange Programs

O-BMT
Start date: January 2, 2019
Phase: Phase 2
Study type: Interventional

This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community health center for buprenorphine treatment.

NCT ID: NCT03015597 Completed - Smoking Cessation Clinical Trials

Pilot Study of Contingency Management for Smoking Cessation

Start date: October 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to see whether contingency management (CM) can be successfully added as an adjunct treatment to standard stop smoking services in outpatients undergoing treatment for opiate addiction. Forty tobacco smoking patients undergoing treatment for opiate addiction will be stratified to a CM intervention for either smoking abstinence or attendance at the clinic, whilst also receiving usual stop smoking services cessation treatment. The intervention will run for five weeks and participants will be followed up six months after the beginning of the study.

NCT ID: NCT02997644 Completed - Opiate Addiction Clinical Trials

Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery

OpiateLEO
Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after elective lower extremity surgery.

NCT ID: NCT02925806 Enrolling by invitation - Drug Abuse Clinical Trials

Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products

Start date: n/a
Phase: N/A
Study type: Observational

A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.

NCT ID: NCT02920775 Enrolling by invitation - Drug Abuse Clinical Trials

Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics

Start date: n/a
Phase: N/A
Study type: Observational

Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could have greater impact on prescribing (e.g., dentists). Trends and changes in monthly prescription volume and average monthly prescription volume will be evaluated by prescriber specialty.

NCT ID: NCT02920762 Enrolling by invitation - Drug Abuse Clinical Trials

Evaluation of Changes in Prescribing Behavior of ER/LA Opioid Prescribers

Start date: n/a
Phase: N/A
Study type: Observational

A study will be performed to evaluate changes in prescribing behavior of prescribers of ER/LA opioids

NCT ID: NCT02867124 Recruiting - Opiate Addiction Clinical Trials

Long-acting Naltrexone for Pre-release Prisoners

Start date: January 1, 2017
Phase: Phase 3
Study type: Interventional

This proposed five-year study will focus on whether the addition of providing XR-NTX treatment at a patients' place of residence will increase adherence and thus efficacy of the medication.Following initial screening, informed consent, and medical examination, pre-release prisoners at each facility will be block randomized (N=240) within gender to either: Condition 1. XR-NTX-OTx (n=120): One injection of XR-NTX in prison, followed by six monthly injections post-release in the community at an opioid treatment program; or Condition 2. XR-NTX+MMTx (n=120): One injection of XR-NTX in prison, followed by six monthly injections post-release in the community at the patient's place of residence.