Open Angle Glaucoma Clinical Trial
Official title:
POSAG: Prevalence of Obstructive Sleep Apnoea in Glaucoma
This study aims to investigate a potential link between Obstructive Sleep Apnoea (OSA) and Open Angle Glaucoma (OAG); initially by determining whether the prevalence of OSA is higher in patients with OAG in comparison to people without glaucoma and if OSA is an independent risk factor for OAG. It will comprehensively phenotype glaucoma patients for variables that may be associated with both OSA and OAG.
Open Angle Glaucoma (OAG) is an eye disease which can lead to irreversible loss of vision
caused by damage to the optic nerve at the back of the eye. It is often associated with
raised fluid pressure in the eye and treated by lowering this pressure. However, despite
treatment, some patients continue to lose vision and it is suspected that other factors are
contributing to the optic nerve damage. Among them is Obstructive Sleep Apnoea (OSA), though
the link between OAG and OSA is controversial.
This study aims to determine whether the prevalence of OSA is higher in patients with OAG in
comparison to people without glaucoma. In addition, it will establish whether OSA is an
independent risk factor for OAG and whether a future randomised controlled trial assessing
the impact of OSA treatment with Continues Positive Airway Pressure (CPAP) on OAG outcomes
would be acceptable and feasible in this population. The usefulness of OSA screening tools,
including oximetry and questionnaires will also be determined. We comprehensively phenotype
glaucoma patients using novel techniques, which include angiographic ocular coherence
tomography and retinal oximetry. Ocular perfusion pressure will be calculated based on
central retinal vein pressure measured by ophthalmodynamometry.
The study is a collaborative project between sleep specialists at Papworth Hospital and
ophthalmologists at Hinchingbrooke Hospital and will involve patients attending glaucoma
clinic and their relatives who will act as a control group. Two study visits will be required
on consecutive days. Participants will undergo a comprehensive ocular examination and a sleep
study in the form of respiratory polysomnography (respiratory PSG) at home. A brief medical
history focused on cardiovascular and metabolic co-morbidities will be taken.
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