Ocular Hypertension Clinical Trial
Official title:
Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging
Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular
pressure (IOP) has been identified as the most important risk factor. However, some patients
progress despite adequate IOP lowering while some subjects with elevated IOP never develop
glaucoma. Other patients develop glaucoma although IOP measurements were always in the normal
range. Therefore, other factors must be involved. In the last years, studies using MRI have
been performed and evidence has accumulated that also changes in retrobulbar structures are
present, in particular in the lateral geniculate nucleus and the visual cortex. However,
these studies were limited by the low spatial resolution of the MRI instruments used.
The investigators propose to overcome this problem by using an ultrahigh-field Magnetom 7T
whole-body MR scanner (Siemens Medical, Germany) installed at the MR Centre of Excellence at
the Medical University of Vienna. This scanner is equipped with a 32-channel head coil and
the SC72 high-performance gradient system and is thus perfectly suited for structural and
functional imaging. The aim of the present study is to investigate whether structural and
functional parameters are altered in patients with primary open angle glaucoma (POAG), normal
tension glaucoma (NTG), ocular hypertension (OHT) compared to healthy control subjects. The
exact topographical survey of intracranial structures such as the LGN and the assessment of
neuronal structures by DTI may allow for the better assessment of therapeutic responses to
new neuroprotective agents.
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