Ocular Hypertension Clinical Trial
Official title:
Anomalies of the Anterior Chamber, Angle, Iris, Cornea and Lens With or Without Glaucoma or Ocular Hypertension
This study will investigate congenital or developmental eye abnormalities that affect the
iris, cornea and lens, and are usually accompanied by elevated pressure within the eye.
These disorders can cause vision loss, and the increased eye pressure can lead to glaucoma,
a condition that may also cause loss of eyesight.
Patients with eye anterior chamber eye disease, such as Axenfeld's syndrome, Rieger's
anomaly, Peter's anomaly, iridocorneal endothelial syndrome, megalocornea, ocular
hypertension, and others, are eligible for this study. Participants will have a medical
examination, family history, and comprehensive eye examination. Tests and procedures may
include photographs of the cornea, iris, and the structure through which fluid that normally
circulates behind the cornea drains out of the eye. Some patients may undergo indentation
tonography to measure how easily this fluid drains. In this procedure, the patient lies on
an examination table and both eyes are numbed with eye drops. A small instrument (tonometer)
is placed on the surface of one eye, and with the other eye, the patient looks at an
overhead light. Other tests may include photographs of the back of the eye and ultrasound
imaging of the structures of the eye. A blood sample may be drawn to study the genetic
disorder responsible for the disease. Patients will have follow-up examinations every 6
months for the duration of the study.
Medical or surgical therapy will be recommended, as appropriate, for patients who develop
elevated eye pressure or vision loss.
Status | Completed |
Enrollment | 100 |
Est. completion date | August 2002 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
The eye conditions to be studied include Axenfeld's syndrome, Rieger's anomaly, Peter's
anomaly, (all with or without glaucoma), Iridocorneal Endothelial syndrome, Aniridia,
Pigment Dispersion syndrome, Megalocornea and other conditions with clinical abnormalities
of the anterior chamber. Patients will not be included in the study if they do not fit the morphologic characteristics of the disease in question or if the patient's general medical condition or other related factors make it impossible for him or her to continue participation in the study. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Eye Institute (NEI) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Eye Institute (NEI) |
United States,
Datson NA, Semina E, van Staalduinen AA, Dauwerse HG, Meershoek EJ, Heus JJ, Frants RR, den Dunnen JT, Murray JC, van Ommen GJ. Closing in on the Rieger syndrome gene on 4q25: mapping translocation breakpoints within a 50-kb region. Am J Hum Genet. 1996 Dec;59(6):1297-305. — View Citation
Semina EV, Datson NA, Leysens NJ, Zabel BU, Carey JC, Bell GI, Bitoun P, Lindgren C, Stevenson T, Frants RR, van Ommen G, Murray JC. Exclusion of epidermal growth factor and high-resolution physical mapping across the Rieger syndrome locus. Am J Hum Genet. 1996 Dec;59(6):1288-96. — View Citation
Semina EV, Reiter R, Leysens NJ, Alward WL, Small KW, Datson NA, Siegel-Bartelt J, Bierke-Nelson D, Bitoun P, Zabel BU, Carey JC, Murray JC. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet. 1996 Dec;14(4):392-9. — View Citation
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