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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05967754
Other study ID # 24/327
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2018
Est. completion date December 1, 2020

Study information

Verified date July 2023
Source Alexandria University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study aimed to correlate serum uric acid levels and PAH in OSAHS patients.


Description:

Obstructive sleep apnea-hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, that accompanies OSAHS increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension. AIM OF THE WORK This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI < 15), moderate OSA (15 ≤ AHI < 30), and severe (30 ≤ AHI < 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and Pulmonary artery systolic pressure calculation was done.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date December 1, 2020
Est. primary completion date October 1, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Clinical diagnosis of OSAHS by overnight polysomnography (AHI = 5/ hr) - =18 years old. Exclusion Criteria: - Other sleep disorders as narcolepsy or hypersomnia were excluded as well as Patients with neuropsychiatric disorders. - Hemodynamically unstable patients - Patients with other chronic respiratory or cardiac diseases - Patients with other known causes of pulmonary hypertension - Patients with any disease or on medication that could alter excretion or urinary metabolism of uric acid such as Excessive uric acid production

Study Design


Intervention

Diagnostic Test:
polysomnography
polysomnography and serum uric acid measurement

Locations

Country Name City State
Egypt Rania Ahmad Sweed Alexandria

Sponsors (1)

Lead Sponsor Collaborator
Alexandria University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients. This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients. one Year
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