Obstructive Sleep Apnea Clinical Trial
Official title:
Comparative Study of Effect of Valsartan 160mg Treatment Versus Continuous Positive Airway Pressure on Arterial Blood Pressure in Patients Who Have an Obstructive Sleep Apnea Syndrome and a Weak or Moderate Hypertension.
The main objective of the study is to compare the decrease of mean arterial blood pressure over 24 hours in patients having obstructive sleep apnea syndrome and weak or moderate hypertension, treated by Valsartan 160mg per day versus continuous Positive Airway Pressure.
It is now well known that cardiovascular risks are increased in patients with obstructive
sleep apnea syndrome (OSAS). Also a link has already been demonstrated between OSAS and
hypertension.
Nowadays, the most efficient treatment of the OSAS is the continuous Positive Airway
Pressure (cPAP). Several studies have also shown that cPAP could reduce arterial blood
pressure of about 3,3 mmHg in OSAS patients. Unfortunately, 40% of the patients either
refuse being treated by cPAP or give up treatment. In parallel, alternative medications are
proposed to patients with moderate OSAS and hypertension, in order to decrease their
cardiovascular risks. A study led on rats has shown the superiority of the beta adrenergic
blocking agents in the decrease of hypertension in OSAS patients.
Our study has also the objective to compare the effects of Valsartan and cPAP on
hypertension in OSAS patients. Those one will be randomized either in the group "treatment
by Valsartan and then by cPAP" or in the group "treatment by cPAP and then Valsartan"
(cross-over study).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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