Obstructive Sleep Apnea Syndrome Clinical Trial
Official title:
Systemic Inflammation and Obstructive Sleep Apnea Syndrome: Effect of Atorvastatin
The aim of this clinical trial is to evaluate the effect of Atorvastatin on the endothelial
function improvement during the obstructive sleep apnea syndrome (OSAS) after 3 months of
treatment, by a double-blind, randomized, placebo-controlled, multi-center study.
An interim analysis will be performed when 25 patients per group will be included.
Secondary objectives of this clinical trial :
- To evaluate the effect of Atorvastatin in comparison with the placebo on the
inflammation occurring during OSAS, after 3 months of treatment.
- To evaluate the effect of Atorvastatin in comparison with the placebo on the
insulin-resistance associated to OSAS, after 3 months of treatment.
- To evaluate the effect of Atorvastatin in comparison with the placebo on the
hypercholesterolemia associated to OSAS, after 3 months of treatment.
- To evaluate at 6 months, the effect of the continuous positive airway pressure (CPAP) +
Atorvastatin association on the previously cited parameters, in comparison with
Atorvastatin, CPAP and placebo.
- To measure the CPAP efficiency in comparison with sham CPAP in patients receiving the
placebo, after 3 months of treatment.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT05164211 -
Didgeridoo Treatment to Improve Pharyngeal Compliance in Obstructive Sleep Apnea-hypopnea Syndrome in Children
|
N/A | |
| Active, not recruiting |
NCT05049928 -
m-Rehab OSA : Impact of a Telerehabilitation Program Associated With CPAP on Severity Markers of Obstructive Sleep Apnea Syndrome
|
N/A | |
| Not yet recruiting |
NCT04538274 -
Trained Patient Involvement to Promote the Resumption of CPAP in Patients Who Have Discontinued Its Use
|
N/A | |
| Completed |
NCT02995837 -
CBF and Childhood OSAS
|
||
| Completed |
NCT02967367 -
Reliability of Consumer Sleep Trackers in Patients Suffering From Obstructive Sleep Apnea Syndrome
|
N/A | |
| Completed |
NCT02180672 -
Steroids for Pediatric Apnea Research in Kids
|
Phase 3 | |
| Recruiting |
NCT01561677 -
Consequences of Obstructive Sleep Apnea Syndrome (OSAS) After Ischemic Subtentorial Stroke.
|
N/A | |
| Completed |
NCT01808508 -
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
|
N/A | |
| Completed |
NCT01193738 -
Osteopathy and Obstructive Sleep Apnea Syndrome
|
N/A | |
| Completed |
NCT01090297 -
Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure
|
N/A | |
| Completed |
NCT00850876 -
Heated Humidified Continuous Positive Airway Pressure and Nasal Physiology
|
N/A | |
| Completed |
NCT00801671 -
Russian Study of the Effect of Continuous Positive Airway Pressure (CPAP) in Hypertension
|
Phase 3 | |
| Completed |
NCT02085720 -
Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance
|
N/A | |
| Recruiting |
NCT00874913 -
Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS)
|
N/A | |
| Completed |
NCT00156442 -
A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate
|
N/A | |
| Completed |
NCT00222963 -
Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents
|
N/A | |
| Withdrawn |
NCT00156455 -
Sleep Disordered Breathing in Children With Single Ventricle Physiology
|
N/A | |
| Completed |
NCT01045499 -
LAGB as a Treatment for Morbid Obesity in Adolescents
|
N/A | |
| Withdrawn |
NCT02559427 -
SPA Therapy in the Treatment of Sleep Apnea Syndrome
|
N/A | |
| Completed |
NCT02522819 -
Feasibility Evaluation of CPAP in the Treatment of Obstructive Sleep Apnea Synchrone in the Acute Phase of Stroke
|
N/A |