Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT05028985 |
Other study ID # |
82090011 |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
January 1, 2021 |
Est. completion date |
December 2025 |
Study information
Verified date |
August 2021 |
Source |
China-Japan Friendship Hospital |
Contact |
Chen Wang |
Phone |
+86 010 69156477 |
Email |
cyh-birm[@]263.net |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Discovery of the pathogenesis and targets in the progression of early chronic obstructive
pulmonary disease
Description:
This project is aimed to investigate and explore the heterogeneity during the progression of
Chronic Obstructive Pulmonary Disease (COPD) in the early stage, utilizing the large-scale
population cohort databases (including "China Pulmonary Health study", "The Cohort Study for
Chronic Obstructive Pulmonary Disease in China" and "Acute Exacerbation of COPD Patient
Registry in China" ), biological sample libraries(including blood, sputum, expiratory air,
bronchoalveolar lavage fluid(BALF), and lung tissue from COPD patients with different stages
and phenotypes), and multi-omics sequencing (including scRNA-seq, metabolomics, proteomics,
and metagenome). We propose to establish a new standard for COPD stages and subtypes. By
analyzing and mining the multi-omics data, it is expected to illustrate the association
between clinical phenotype and molecular, cellular and tissue heterogeneities, thus reveal
biomarkers related to the progression, clinical phenotypes, and prognosis of early-stage COPD
disease.In addition, we will construct different types and stages of COPD animal models for
further mechanism studies, such as the different pathogenic factors, innate and adaptive
immunity, and the airway microbial ecosystem, so that we can discovered more potential
therapeutic target for early-stage COPD. This project can bring a new insight and scientific
evidence for COPD treatment.