Obstructive Pulmonary Disease Clinical Trial
— EC-CPHSOfficial title:
A Cohort Study of Early Chronic Obstructive Pulmonary Disease for China Pulmonary Health Study Stage II
NCT number | NCT05028985 |
Other study ID # | 82090011 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2021 |
Est. completion date | December 2025 |
Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease
Status | Recruiting |
Enrollment | 400 |
Est. completion date | December 2025 |
Est. primary completion date | January 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - younger than 50 years - smoking more than 10 pack-years - early airflow limitation(post-bronchodilator FEV1/FVC< lower limit of normal) Exclusion Criteria: - cancer - other respiratory diseases - mental illness |
Country | Name | City | State |
---|---|---|---|
China | Capital Medical University | Beijing | |
China | China-Japan Friendship Hospital | Beijing | |
China | Institue of Basic Medical Sciences Chinese Academy of Medical Sciences | Beijing | |
China | Peking University Third Hospital | Beijing | |
China | Second Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou | Zhejiang |
China | Shanghai Ninth People's Hospital, Shanghai JiaoTong university school of medicine | Shanghai |
Lead Sponsor | Collaborator |
---|---|
China-Japan Friendship Hospital | Capital Medical University, Chinese Academy of Medical Sciences, Peking University Third Hospital, Second Affiliated Hospital, School of Medicine, Zhejiang University, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | FEV1 annual decline in clinical practice | FEV1 measured by portable spirometry can reflect the progression of early COPD. | 2021.1-2024.12 | |
Secondary | dyspnea symptoms | Severity of dyspnea is positively correlated with COPD severity. | 2021.1-2024.12 | |
Secondary | frequency of COPD acute exacerbation | The frequency of COPD acute exacerbation refers to the number of acute exacerbations per year. | 2021.1-2024.12 | |
Secondary | chest imaging changes | Emphysema and obstruction in small airway will be evaluated by chest computed tomography(CT). | 2021.1-2024.12 | |
Secondary | systemic complications | Whether there are systemic complications is related to the prognosis of patients. | 2021.1-2024.12 |
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