Obstetric Labor, Premature Clinical Trial
Official title:
Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone
NCT number | NCT03211338 |
Other study ID # | HYMC-0061-17 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | July 15, 2017 |
Est. completion date | June 6, 2022 |
Verified date | June 2022 |
Source | Hillel Yaffe Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
Status | Completed |
Enrollment | 115 |
Est. completion date | June 6, 2022 |
Est. primary completion date | June 6, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Placentas from term and preterm deliveries - Singleton pregnancy - Consent to participate Exclusion Criteria: - Pregnancies with obstetric complications - Multiple gestation - Maternal illness or fetal malformation known pre-delivery |
Country | Name | City | State |
---|---|---|---|
Israel | Hillel Yaffe Medical Center | H_adera |
Lead Sponsor | Collaborator |
---|---|
Hillel Yaffe Medical Center |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Inflammation characteristic effects of progesterone on preterm and term placentas | Differences observed in cytokine profiles of IMC cells from term and preterm placentas cultured with and without progesterone | One year | |
Primary | Maturation effects of progesterone on preterm and term placentas | Differences observed in maturation of IMC cells into DC cells in term and preterm placentas | One year |
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